Forough Reza, Scarcello Catherine, Perkins Matthew
Bellevue College, Science Division, Bellevue, WA, USA.
J Tehran Heart Cent. 2011 Nov;6(4):179-86. Epub 2011 Nov 30.
HISTORICALLY, BIOMARKERS HAVE BEEN USED IN TWO MAJOR WAYS TO MAINTAIN AND IMPROVE BETTER HEALTH STATUS: first, for diagnostic purposes, and second, as specific targets to treat various diseases. A new era in treatment and even cure for the some diseases using reprograming of somatic cells is about to be born. In this approach, scientists are successfully taking human skin cells (previously considered terminally-differentiated cells) and re-programming them into functional cardiac myocytes and other cell types in vitro. A cell reprograming approach for treatment of cardiovascular diseases will revolutionize the field of medicine and significantly expand the human lifetime. Availability of a comprehensive catalogue for cardiac biomarkers is necessary for developing cell reprograming modalities to treat cardiac diseases, as well as for determining the progress of reprogrammed cells as they become cardiac cells. In this review, we present a comprehensive survey of the cardiac biomarkers currently known.
从历史上看，生物标志物主要以两种方式用于维持和改善健康状况：第一，用于诊断目的；第二，作为治疗各种疾病的特定靶点。利用体细胞重编程治疗甚至治愈某些疾病的新时代即将诞生。在这种方法中，科学家们成功地将人类皮肤细胞（以前被认为是终末分化细胞）在体外重新编程为功能性心肌细胞和其他细胞类型。用于治疗心血管疾病的细胞重编程方法将彻底改变医学领域，并显著延长人类寿命。开发用于治疗心脏病的细胞重编程模式以及确定重编程细胞向心脏细胞转变的进程，都需要有一份全面的心脏生物标志物目录。在这篇综述中，我们对目前已知的心脏生物标志物进行了全面的调查。
