Department of Pediatric Respiratory Medicine and Allergy, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands.
Arch Dis Child. 2012 Dec;97(12):1039-42. doi: 10.1136/archdischild-2011-301304. Epub 2012 Oct 16.
The primary objective of this prospective cohort study was to determine the effect of weight loss on pulmonary function values in extremely obese children.
Obese children participated in a 26-week in-hospital or outpatient multidisciplinary treatment programme. Waist circumference was measured and pulmonary function tests were performed at enrolment and after 6 months.
The data of 112 children were analysed. The children had a mean age of 14.4 (range 8.5-18.9) years and 62.5% were girls. The mean SD score-body mass index (SDS-BMI) was +3.38 at baseline and +2.91 after the intervention. Lung function improved significantly: functional vital capacity increased by 3.08% (95% CI 1.16% to 5.00%) of the predicted value, forced expiratory volume in 1 s (FEV(1)) by 2.91% (95% CI 1.11% to 4.71%) of the predicted value, total lung capacity by 2.27% (95% CI 1.16% to 5.00%) of the predicted value, and expiratory reserve volume (ERV) by 14.8% (95% CI 8.66% to 20.88%) of the predicted value. The increase in ERV correlated with the reduction in SDS-BMI and with the reduction in waist circumference. FEV(1) did not correlate with the reduction in either SDS-BMI or waist circumference.
Weight loss in severely obese children correlated with an improvement in lung function, especially ERV. The improvement in ERV correlated with the decrease in SDS-BMI and waist circumference.
本前瞻性队列研究的主要目的是确定减肥对极度肥胖儿童肺功能值的影响。
肥胖儿童参加了 26 周的住院或门诊多学科治疗计划。在入组时和 6 个月后测量腰围并进行肺功能检查。
分析了 112 名儿童的数据。儿童的平均年龄为 14.4 岁（范围为 8.5-18.9 岁），其中 62.5%为女孩。基线时的平均标准差-体重指数（SDS-BMI）为+3.38，干预后为+2.91。肺功能显著改善：功能肺活量增加预测值的 3.08%（95%可信区间 1.16%至 5.00%），1 秒用力呼气量（FEV1）增加预测值的 2.91%（95%可信区间 1.11%至 4.71%），总肺活量增加预测值的 2.27%（95%可信区间 1.16%至 5.00%），呼气储备量（ERV）增加预测值的 14.8%（95%可信区间 8.66%至 20.88%）。ERV 的增加与 SDS-BMI 的降低以及腰围的减少相关。FEV1 与 SDS-BMI 或腰围的减少均无相关性。
严重肥胖儿童的体重减轻与肺功能的改善相关，尤其是 ERV。ERV 的改善与 SDS-BMI 和腰围的减少相关。
