Varrela J, Alvesalo L, Mayhall J
Institute of Dentistry, University of Turku, Finland.
J Dent Res. 1990 Feb;69(2):494-5. doi: 10.1177/00220345900690021501.
Orthopantomograms of 87 45,X females, 61 first-degree female relatives of these females, and a population sample of 113 normal females and 44 normal males were examined for the occurrence of taurodontism in mandibular molars. In the sample of 45,X females, two showed taurodont lower molars. In one of them, a hypotaurodont second molar was detected, while hypotaurodont third molars were found in the other. Three of the females' relatives and four of the population control females showed taurodontism, three unilaterally and four bilaterally. In all cases, the affected teeth were hypotaurodont. The results suggest that taurodontism occurs in 45,X females with a frequency similar to that in normal females. This result is not in accordance with the hypothesis that low mitotic activity of the chromosomally abnormal cells is an etiological factor in the development of taurodontism. The present findings, together with earlier results, suggest that the gene content of the X chromosome, rather than the amount of heterochromatin, is the cause of taurodontism in individuals with chromosome aneuploidy.
对87名45,X女性、这些女性的61名一级女性亲属以及113名正常女性和44名正常男性的全口曲面断层片进行检查，以观察下颌磨牙牛牙样变的发生情况。在45,X女性样本中，有两人下颌磨牙出现牛牙样变。其中一人检测到一颗低牛牙症的第二磨牙，另一人则发现了低牛牙症的第三磨牙。这些女性亲属中有三人以及人群对照中的四名女性出现了牛牙样变，三人单侧出现，四人双侧出现。在所有病例中，受累牙齿均为低牛牙症。结果表明，45,X女性中牛牙样变的发生率与正常女性相似。这一结果与以下假设不符：染色体异常细胞的低有丝分裂活性是牛牙样变发生的病因。目前的研究结果与早期结果一起表明，X染色体的基因组成，而非异染色质的量，是染色体非整倍体个体中牛牙样变的原因。
