Kusiak Aida, Kochańska Barbara, Świetlik Dariusz, Cydejko Aleksandra, Maj Adrian
Department of Periodontology and Oral Mucosa Diseases, Medical University of Gdańsk, Poland.
Department of Conservative Dentistry, Medical University of Gdańsk, Poland.
Saudi Dent J. 2021 Nov;33(7):448-452. doi: 10.1016/j.sdentj.2020.12.003. Epub 2020 Dec 16.
The aim of this study was to evaluate the caries intensity and () counts in patients with Turner syndrome.
Nineteen patients aged 20-40 years were clinically and cytogenetically diagnosed with Turner syndrome (45, X). The karyotype was determined by chromosome analysis of peripheral blood lymphocytes. The control group comprised 47 healthy women aged 21-40 years. Both groups included non-smokers with no specific diet, such as a vegetarian or vegan diet, who were generally healthy with good oral hygiene and periodontal condition. Patients treated with antibiotics or steroid preparations in the past 6 months or with diseases or conditions that might affect the oral mucosal environment, such as disorders of salivary secretion and diabetes, were excluded from the study. Decayed, missing, and filled teeth (DMFT) scores and counts in saliva were determined.
No colony growth of was noticed in 53% of patients with Turner syndrome and 4.2% of controls (p < 0.001). Colony counts of ≥ 10 in saliva were observed in none of the patients with Turner syndrome but in 66% of controls (p < 0.001). The mean DMFT score was 1.63 ± 2.52 in patients with Turner syndrome and 14.49 ± 6.88 in controls. Statistically significant differences between the two groups were observed (p < 0.05).
Patients with genetic disorders may have different severities of caries and counts in saliva compared to those without genetic disorders. Further studies on saliva properties and genes located on the X chromosome could contribute to determining the effect of the X chromosome on the pathological processes in the oral cavity.
本研究旨在评估特纳综合征患者的龋病严重程度及（某菌）计数。
19例年龄在20至40岁的患者经临床和细胞遗传学诊断为特纳综合征（45,X）。通过外周血淋巴细胞染色体分析确定核型。对照组由47名年龄在21至40岁的健康女性组成。两组均为不吸烟、无特殊饮食（如素食或纯素饮食）、一般健康且口腔卫生和牙周状况良好的人群。过去6个月内接受过抗生素或类固醇制剂治疗，或患有可能影响口腔黏膜环境的疾病或状况（如唾液分泌障碍和糖尿病）的患者被排除在研究之外。确定龋失补牙（DMFT）评分及唾液中（某菌）计数。
53%的特纳综合征患者未观察到（某菌）菌落生长，而对照组为4.2%（p<0.001）。特纳综合征患者唾液中（某菌）菌落计数≥10的情况未出现，而对照组为66%（p<0.001）。特纳综合征患者的平均DMFT评分为1.63±2.52，对照组为14.49±6.88。两组间存在统计学显著差异（p<0.05）。
与非遗传性疾病患者相比，遗传性疾病患者可能有不同严重程度的龋齿及唾液中（某菌）计数。对唾液特性和X染色体上基因的进一步研究可能有助于确定X染色体对口腔病理过程的影响。
