Cojocaru Elena, Zamfir Carmen, Zamosteanu Nina, Trandafirescu Mioara, Cotuţiu C
Disciplina de Histologie, Facultatea de Medicină, Universitatea de Medicină si Farmacie "Grigore T. Popa", Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2012 Jan-Mar;116(1):200-6.
High levels of high-density lipoprotein cholesterol (HDL) are associated with a reduced risk of cardiovascular disease, so that many studies focus on modify HDL levels for therapeutic purpose.
The present research aims to highlight changes in plasma levels of HDL-cholesterol in experimental animals with a high-fat diet associated with some branched aminoacids--valine and leucine.
The experiment was realised on 32 male Wistar rats, which were divided in four groups: group I--received a standard diet; group II--was fed with cholesterol (C), group III (C + V)--cholesterol and valine and group IV (C + L)--cholesterol and leucine. After 8 weeks animals were evaluated in relation with lipids levels in the blood.
The average values of HDL-cholesterol in group who received only cholesterol (C) were significantly lower compared with group III who received cholesterol and valine (C + V) or group IV that received cholesterol and leucine (C + L) (p < 0.001), after one month and at the end of the experiment.
Our results showed that valine and leucine increased the serum levels of HDL-cholesterol and therefore they are useful components in coronary artery disease risk reduction. The association of these aminoacids in human diets can improve clinical conditions associated with hyperlipidaemia such as atherosclerosis.
高密度脂蛋白胆固醇（HDL）水平升高与心血管疾病风险降低相关，因此许多研究聚焦于为治疗目的而改变HDL水平。
本研究旨在突出高脂饮食联合某些支链氨基酸（缬氨酸和亮氨酸）的实验动物血浆中HDL胆固醇水平的变化。
对32只雄性Wistar大鼠进行实验，将其分为四组：第一组给予标准饮食；第二组喂食胆固醇（C），第三组（C + V）给予胆固醇和缬氨酸，第四组（C + L）给予胆固醇和亮氨酸。8周后评估动物的血脂水平。
仅接受胆固醇（C）的组中HDL胆固醇的平均值，与接受胆固醇和缬氨酸（C + V）的第三组或接受胆固醇和亮氨酸（C + L）的第四组相比，在实验一个月后和结束时均显著降低（p < 0.001）。
我们的结果表明，缬氨酸和亮氨酸可提高血清HDL胆固醇水平，因此它们是降低冠状动脉疾病风险的有用成分。这些氨基酸在人类饮食中的联合应用可改善与高脂血症相关的临床状况，如动脉粥样硬化。
