Grigorjeva M E, Myasoedov N F, Lyapina L A, Obergan T Y, Andreeva L A
Faculty of Biology, Moscow State University, Moscow, 119992, Russia.
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia.
Dokl Biochem Biophys. 2018 Mar;479(1):59-61. doi: 10.1134/S1607672918020011. Epub 2018 May 19.
A comparative study of the influence of regulatory proline peptides Pro-Gly-Pro, Pro-Arg-Pro, Pro-Gly-Pro-Leu, and Arg-Pro-Gly-Pro on the state of the hemostasis system was carried out in an experiment on male rats with metabolic syndrome. Under these conditions, repeated (7-fold) intranasal administration of the peptides in a daily dose of 50 μg/kg resulted in an increase in the anticoagulant potential of the blood, namely, in an increase in the anticoagulant, fibrinolytic, and antiplatelet activity 20 h and 7 days after the last peptide injection. The arginine-containing peptide Arg-Pro-Gly-Pro had the most pronounced and stable effect on haemostasis under these experimental conditions.
在患有代谢综合征的雄性大鼠实验中，对调节性脯氨酸肽Pro-Gly-Pro、Pro-Arg-Pro、Pro-Gly-Pro-Leu和Arg-Pro-Gly-Pro对止血系统状态的影响进行了比较研究。在这些条件下，以每日50μg/kg的剂量重复（7次）鼻内给药这些肽，导致血液抗凝潜力增加，即在最后一次肽注射后20小时和7天，抗凝、纤维蛋白溶解和抗血小板活性增加。在这些实验条件下，含精氨酸的肽Arg-Pro-Gly-Pro对止血具有最显著和稳定的作用。
