Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Expert Opin Biol Ther. 2013 Jan;13(1):67-76. doi: 10.1517/14712598.2013.727390. Epub 2012 Oct 18.
Cachexia is a multiorgan syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting and inflammation, being often associated with anorexia.
The aim of the present review is to examine the impact of ghrelin and its agonists in the treatment of cancer cachexia, both at the biochemical and physiological level a taking into account new clinical and experimental data related to the effects of ghrelin on food intake and metabolism. The methodology undertaken includes both personal publications and other obtained by Medline search.
Based on experimental evidence, it is concluded that ghrelin strategies are good candidates for muscle wasting treatment because ghrelin levels are elevated in cancer cachexia and ghrelin controls mediators involved in the cachectic process. Future clinical studies addressed at the interaction between the peptide and protein turnover in human skeletal muscle should be performed.
恶病质是一种与癌症相关的多器官综合征，其特征是体重减轻、肌肉和脂肪组织消耗以及炎症，常伴有厌食。
本综述旨在检查胃饥饿素及其激动剂在治疗癌症恶病质方面的作用，既考虑到与胃饥饿素对食物摄入和代谢的影响相关的新的临床和实验数据，又考虑到生物化学和生理学水平。所采用的方法包括个人出版物和通过 Medline 搜索获得的其他出版物。
基于实验证据，可以得出结论，胃饥饿素策略是治疗肌肉消耗的良好候选物，因为在癌症恶病质中胃饥饿素水平升高，并且胃饥饿素控制参与恶病质过程的介质。应该进行未来的临床研究，以研究肽和蛋白质在人类骨骼肌中的相互作用。
