Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China.
Eur J Radiol. 2013 Feb;82(2):e95-9. doi: 10.1016/j.ejrad.2012.09.006. Epub 2012 Oct 16.
Several studies suggest that iron deposition may play a role in multiple sclerosis (MS) pathology. Three-dimensional (3D) enhanced T2*-weighted angiography (ESWAN) at 3T was used to quantify iron deposition in the precentral grey matter in MS and its relationship with disease duration, atrophy and Expanded Disability Status Scale (EDSS) scores.
We recruited 33 patients with diagnosis of clinically definite MS and 31 age- and sex-matched healthy controls who underwent conventional brain MRI, 3D-ESWAN and 3D T1sequences. We obtained the mean phase values (MPVs) of the precentral grey matter on ESWAN-filtered phase images and volume of the precentral gyrus on 3D T1 images. We investigated the correlation between precentral grey matter MPVs, precentral gyrus volume, disease duration and EDSS scores of MS patients and healthy controls.
The precentral grey matter MPVs in MS patients and controls were 1870.83 ± 56.61 and 1899.22 ± 51.73 respectively and had significant difference in the MS group vs. the control group (t=-2.09, P=0.04). There was significant negative correlation between precentral grey matter MPVs and disease duration (r=-0.365, P=0.03). No correlation was found between MPVs and EDSS scores. Mean precentral gyrus volume in MS patients was 4368.55 ± 867.78 whereas in controls was 5701.00 ± 1184.03 with significant difference between volume of the precentral gyrus in MS patients compared to healthy controls (t=-5.167, P<0.001). There was a positive correlation between MPVs and precentral gyrus volume (r=0.291, P=0.020).
Our study demonstrated that quantitative assessment of abnormal iron deposition in the precentral grey matter in MS patients can be measured using 3D-ESWAN.
多项研究表明，铁沉积可能在多发性硬化症（MS）的发病机制中发挥作用。本研究采用 3T 下的三维增强 T2*-加权血管造影（ESWAN）定量检测 MS 患者中央前回灰质中的铁沉积，并探讨其与病程、萎缩和扩展残疾状况量表（EDSS）评分的关系。
本研究共纳入 33 例临床确诊的 MS 患者和 31 名年龄和性别匹配的健康对照者，所有受试者均行常规脑 MRI、3D-ESWAN 和 3D T1 序列扫描。我们在 ESWAN 滤波相位图像上获得中央前回灰质的平均相位值（MPV），并在 3D T1 图像上获得中央前回体积。我们分析了 MS 患者和健康对照组中央前回灰质 MPV、中央前回体积、病程和 EDSS 评分之间的相关性。
MS 患者和对照组中央前回灰质 MPV 分别为 1870.83 ± 56.61 和 1899.22 ± 51.73，两组间差异有统计学意义（t=-2.09，P=0.04）。MS 组中央前回灰质 MPV 与病程呈显著负相关（r=-0.365，P=0.03）。MPV 与 EDSS 评分之间无相关性。MS 患者的中央前回体积平均为 4368.55 ± 867.78，而对照组为 5701.00 ± 1184.03，两组间差异有统计学意义（t=-5.167，P<0.001）。MS 患者中央前回灰质 MPV 与中央前回体积呈正相关（r=0.291，P=0.020）。
本研究采用 3D-ESWAN 检测到 MS 患者中央前回灰质中异常铁沉积的定量评估。
