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Association between biomarkers of obesity and risk of high-grade prostatic intraepithelial neoplasia and prostate cancer--evidence of effect modification by prostate size.肥胖生物标志物与高级别前列腺上皮内瘤变和前列腺癌风险的关联--前列腺体积对作用的影响。
Cancer Lett. 2013 Jan 28;328(2):345-52. doi: 10.1016/j.canlet.2012.10.010. Epub 2012 Oct 16.
2
Statin use linked with a decrease in the conversion from high-grade prostatic intraepithelial neoplasia (HGPIN) to prostate cancer.使用他汀类药物可降低高级别前列腺上皮内瘤变（HGPIN）向前列腺癌的转化。
Carcinogenesis. 2018 May 28;39(6):819-825. doi: 10.1093/carcin/bgy050.
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High grade intraepithelial neoplasia of prostate is associated with values of prostate specific antigen related parameters intermediate between prostate cancer and normal levels.前列腺高级别上皮内瘤与前列腺特异性抗原相关参数的值有关，这些参数的值介于前列腺癌和正常水平之间。
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Is low-grade prostatic intraepithelial neoplasia a risk factor for cancer?低级别前列腺上皮内瘤变是癌症的危险因素吗？
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Current significance of the finding of high grade prostatic intraepithelial neoplasia in the prostate biopsy.前列腺活检中高级别前列腺上皮内瘤变发现的当前意义。
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Low testosterone level predicts prostate cancer in re-biopsy in patients with high grade prostatic intraepithelial neoplasia.低睾酮水平预测高级别前列腺上皮内瘤变患者再次活检中的前列腺癌。
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Predictors of prostate cancer on extended biopsy in patients with high-grade prostatic intraepithelial neoplasia: a multivariate analysis model.高级别前列腺上皮内瘤变患者经扩展活检诊断前列腺癌的预测因素：多变量分析模型
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Widespread high grade prostatic intraepithelial neoplasia on biopsy predicts the risk of prostate cancer: a 12 months analysis after three consecutive prostate biopsies.活检发现广泛的高级别前列腺上皮内瘤变可预测前列腺癌风险：连续三次前列腺活检后12个月的分析
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Statin use linked with a decrease in the conversion from high-grade prostatic intraepithelial neoplasia (HGPIN) to prostate cancer.使用他汀类药物可降低高级别前列腺上皮内瘤变（HGPIN）向前列腺癌的转化。
Carcinogenesis. 2018 May 28;39(6):819-825. doi: 10.1093/carcin/bgy050.
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Long-term supplementation of decaffeinated green tea extract does not modify body weight or abdominal obesity in a randomized trial of men at high risk for prostate cancer.在一项针对前列腺癌高危男性的随机试验中，长期补充脱咖啡因绿茶提取物不会改变体重或腹部肥胖情况。
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Larger men have larger prostates: Detection bias in epidemiologic studies of obesity and prostate cancer risk.体型较大的男性前列腺也较大：肥胖与前列腺癌风险的流行病学研究中的检测偏倚。
Prostate. 2017 Jun;77(9):949-954. doi: 10.1002/pros.23350. Epub 2017 Mar 27.
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Waist-hip Ratio (WHR), a Better Predictor for Prostate Cancer than Body Mass Index (BMI): Results from a Chinese Hospital-based Biopsy Cohort.腰围臀围比（WHR）是比身体质量指数（BMI）更好的前列腺癌预测指标：来自中国医院前列腺穿刺活检队列的研究结果。
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Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study.代谢综合征诊断与广泛的高级别前列腺上皮内瘤变显著增加前列腺癌风险：一项多中心活检研究的结果
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本文引用的文献

1
Association between physical activity, lower urinary tract symptoms (LUTS) and prostate volume.体力活动与下尿路症状（LUTS）和前列腺体积的关系。
BJU Int. 2013 Jan;111(1):122-8. doi: 10.1111/j.1464-410X.2012.11287.x. Epub 2012 Jun 22.
2
Measuring adiposity in patients: the utility of body mass index (BMI), percent body fat, and leptin.衡量患者的肥胖程度：体重指数 (BMI)、体脂肪百分比和瘦素的应用。
PLoS One. 2012;7(4):e33308. doi: 10.1371/journal.pone.0033308. Epub 2012 Apr 2.
3
Obesity-related systemic factors promote an invasive phenotype in prostate cancer cells.肥胖相关的系统性因素促进前列腺癌细胞的侵袭表型。
Prostate Cancer Prostatic Dis. 2012 Jun;15(2):135-43. doi: 10.1038/pcan.2011.54. Epub 2012 Feb 14.
4
Obesity and Cancer Screening according to Race and Gender.根据种族和性别进行的肥胖与癌症筛查
J Obes. 2011;2011:218250. doi: 10.1155/2011/218250. Epub 2011 Dec 15.
5
Weight change and prostate cancer incidence and mortality.体重变化与前列腺癌的发病和死亡风险。
Int J Cancer. 2012 Oct 1;131(7):1711-9. doi: 10.1002/ijc.27414. Epub 2012 Feb 28.
6
Prostatic intraepithelial neoplasia: its morphological and molecular diagnosis and clinical significance.前列腺上皮内瘤变：其形态学和分子诊断及临床意义。
BJU Int. 2011 Nov;108(9):1394-401. doi: 10.1111/j.1464-410X.2011.010413.x. Epub 2011 Aug 26.
7
Time-varying incidence of cancer after the onset of type 2 diabetes: evidence of potential detection bias.2 型糖尿病发病后癌症发病率的时变：潜在检测偏倚的证据。
Diabetologia. 2011 Sep;54(9):2263-71. doi: 10.1007/s00125-011-2242-1. Epub 2011 Jul 12.
8
Leptin role in the rat prostate ventral lobe.瘦素在大鼠前列腺腹叶中的作用。
Fertil Steril. 2011 Mar 15;95(4):1490-3.e1. doi: 10.1016/j.fertnstert.2010.12.029. Epub 2011 Jan 22.
9
Influence of obesity on the incidence and treatment of genitourinary malignancies.肥胖对泌尿生殖系统恶性肿瘤的发病率和治疗的影响。
Urol Oncol. 2011 Sep-Oct;29(5):476-86. doi: 10.1016/j.urolonc.2009.12.011. Epub 2010 Dec 13.
10
Energetics in colorectal and prostate cancer.结直肠癌和前列腺癌的能量学
J Clin Oncol. 2010 Sep 10;28(26):4066-73. doi: 10.1200/JCO.2009.26.8797. Epub 2010 Jul 19.

肥胖生物标志物与高级别前列腺上皮内瘤变和前列腺癌风险的关联--前列腺体积对作用的影响。

Association between biomarkers of obesity and risk of high-grade prostatic intraepithelial neoplasia and prostate cancer--evidence of effect modification by prostate size.

机构信息

Vanderbilt University Medical Center, Division of Epidemiology, Nashville, TN 37203, United States.

出版信息

Cancer Lett. 2013 Jan 28;328(2):345-52. doi: 10.1016/j.canlet.2012.10.010. Epub 2012 Oct 16.

DOI:10.1016/j.canlet.2012.10.010
PMID:23079532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3513505/
Abstract

Prostate enlargement is common with aging and obesity. We investigated the association between obesity and prostate cancer controlling for differential detection related to prostate enlargement. In an analysis of 500 men, we found body mass index, waist-hip ratio, and blood leptin levels were significantly associated with high-grade PC, but only among men without prostate enlargement. Leptin was also significantly associated with high-grade prostatic intraepithelial neoplasia (HGPIN) in the absence of prostate enlargement. Our results suggest obesity advances prostate carcinogenesis, and that detection biases at prostate biopsy may explain past inconsistencies in the association between obesity and PC.

摘要

前列腺增大是衰老和肥胖的常见现象。我们研究了肥胖与前列腺癌之间的关系，同时控制了与前列腺增大相关的差异检测。在对 500 名男性的分析中，我们发现体重指数、腰围臀围比和血液瘦素水平与高级别前列腺癌显著相关，但仅在没有前列腺增大的男性中。在没有前列腺增大的情况下，瘦素也与高级别前列腺上皮内瘤变（HGPIN）显著相关。我们的结果表明肥胖会促进前列腺癌的发生，而前列腺活检中的检测偏差可能解释了过去肥胖与前列腺癌之间关联的不一致性。