Acikbas I, Tomatir A G, Akdag B, Koksal A
Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Genet Mol Res. 2012 Dec 19;11(4):4640-5. doi: 10.4238/2012.September.10.1.
Down syndrome (DS) is the most frequent chromosome abnormality among live births. Its prevalence increases with maternal age, and can be diagnosed by antenatal screening. We examined prevalence variations of DS in Denizli, Turkey, through a retrospective study. Sixteen years of survey data were retrieved from the two main state hospital registries from records between 1994 and 2010. We identified 113 DS live births in Denizli for 16 years. The prevalence of DS was 9.07 per 10,000 live births before the year 2000 and 9.90 after 2000. The prevalence did not change significantly. The population in Turkey is still young; the fertility rate is high in women under 35 years old and prenatal screening programs are extensively applied; for these reasons, the prevalence of DS has remained stable during these 16 years.
唐氏综合征（DS）是活产儿中最常见的染色体异常疾病。其发病率随母亲年龄增长而增加，可通过产前筛查进行诊断。我们通过一项回顾性研究调查了土耳其代尼兹利市唐氏综合征的发病率变化情况。从两个主要的国立医院登记处检索了1994年至2010年间16年的调查数据。我们确定代尼兹利市在这16年中有113例唐氏综合征活产儿。2000年前唐氏综合征的发病率为每10000例活产儿中有9.07例，2000年后为9.90例。发病率没有显著变化。土耳其人口仍然年轻；35岁以下女性的生育率较高，并且广泛应用产前筛查项目；由于这些原因，在这16年中唐氏综合征的发病率一直保持稳定。
