Janusz J M, Gardlik J M, Young P A, Burkes R V, Stoll S J, Estelle A F, Riley C M
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239-8707.
J Med Chem. 1990 Mar;33(3):1052-61. doi: 10.1021/jm00165a027.
Twenty esters of L-aspartyl-D-phenylglycine, as well as two substituted analogues, an o-fluoro and a p-hydroxy-phenylglycine ester, were prepared. The L-aspartyl-D-phenylglycine (-)-alpha- and (+)-beta-fenchyl esters had the highest sweetness potency at 1200 and 3700 times that of sucrose, respectively. The high potency of these sweeteners is surprising as the phenyl group occupies a position previously believed to accommodate only much smaller groups.
