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Peptide sweeteners. 5. Side-chain homologues relating zwitterionic and trifluoroacetylated amino acid anilide and dipeptide sweeteners.

作者信息

Kawai M, Nyfeler R, Berman J M, Goodman M

出版信息

J Med Chem. 1982 Apr;25(4):397-402. doi: 10.1021/jm00346a013.

DOI:10.1021/jm00346a013
PMID:7069717
Abstract

Side-chain homologues of sweet trifluoroacetyl-alpha-L-aspartyl-p-cyanoanilide have been synthesized and tasted. Removal of the trifluoroacetyl group only changes the potency of sweet taste, not the taste property. These results have been compared with the structure-taste relationships of dipeptide sweeteners. An informative discontinuity of taste effects was found to exist with novel aminomalonyl dipeptide derivatives. The results are explained on topochemical grounds.

摘要

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