L-甲硫氨酸对子宫段对乙酰胆碱和高钾氯化钾收缩反应的增强作用主要归因于钙摄取的增强。

Enhancement by L-methionine on the contractile response of uterine segments to acetylcholine and high KCl is mainly due to enhancement of Ca uptake.

作者信息

Ichida S, Yoshioka K, Ariyoshi S, Fujisue T

机构信息

Department of Biological Chemistry, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Japan.

出版信息

Jpn J Pharmacol. 1990 Jan;52(1):154-9. doi: 10.1254/jjp.52.154.

DOI:10.1254/jjp.52.154

PMID:2308235

Abstract

Acetylcholine (ACh)- and high KCl-stimulated 45Ca uptake into rat uterine segments was inhibited by 3-deazaadenosine (3-DAA) plus homocysteine thiolactone (HCTL), and this inhibitory effect was attenuated by L-methionine (L-Met). Ca-depleted Ringer solution in which uterine muscle had been incubated with L-Met did not enhance the contractile response of another uterine segment to ACh and high KCl in the presence of 3-DAA plus HCTL. These findings together with previous results suggest that the enhancing effect of L-Met on the contractile responses to ACh and high KCl is mainly due to an increase in Ca2+ uptake into the uterine muscle.

摘要

3-脱氮腺苷（3-DAA）加同型半胱氨酸硫内酯（HCTL）可抑制乙酰胆碱（ACh）和高钾刺激的45Ca进入大鼠子宫段，而L-蛋氨酸（L-Met）可减弱这种抑制作用。在3-DAA加HCTL存在的情况下，用L-Met孵育子宫肌的无钙林格液并不能增强另一子宫段对ACh和高钾的收缩反应。这些发现与先前的结果共同表明，L-Met对ACh和高钾收缩反应的增强作用主要是由于子宫肌Ca2+摄取增加所致。