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大鼠子宫中乙酰胆碱诱导的钙离子内流与磷脂酸标记之间不存在相关性。

Absence of correlation between ACh-induced Ca influx and phosphatidic acid labeling in rat uterus.

作者信息

Ichida S, Moriyama M, Hirooka Y, Okazaki Y, Yoshioka K

出版信息

Eur J Pharmacol. 1984 Nov 27;106(3):657-60. doi: 10.1016/0014-2999(84)90075-x.

Abstract

Rat uterine smooth muscle was preincubated in Ca-depleted modified Locke-Ringer solution to investigate the correlation between the 32Pi incorporation into phosphatidic acid induced by acetylcholine and the contractile response to acetylcholine induced by the addition of CaCl2 (Ca influx). The results showed that in rat uterine smooth muscle under these conditions phosphatidic acid does not act as a Ca ionophore or as a trigger for opening the Ca channel.

摘要

将大鼠子宫平滑肌在缺钙的改良洛克-林格溶液中预孵育,以研究乙酰胆碱诱导的32Pi掺入磷脂酸与添加氯化钙(钙离子内流)诱导的对乙酰胆碱的收缩反应之间的相关性。结果表明,在这些条件下的大鼠子宫平滑肌中,磷脂酸既不充当钙离子载体,也不是打开钙通道的触发因素。

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