紫外线 A1 光疗治疗蕈样肉芽肿。
Ultraviolet A1 phototherapy for mycosis fungoides.
机构信息
Department of Dermatology, Poznan Medical University of Sciences, Poznan, Poland.
出版信息
Clin Exp Dermatol. 2013 Mar;38(2):126-30. doi: 10.1111/ced.12001. Epub 2012 Oct 22.
BACKGROUND
Mycosis fungoides (MF) is the most common form of primary cutaneous lymphoma, and is characterized by a malignant proliferation of CD4+ cells. Psoralen ultraviolet A (PUVA) irradiation is the most common treatment for cutaneous lesions. However, PUVA carries the risk of adverse reactions to psoralens and long-term risk of skin cancer. UVA1 may be a safer alternative.
AIM
To assess the efficacy of UVA1 phototherapy in patients with early-stage MF (T1-T2).
METHODS
Four patients with early-stage MF were treated with 1630-2710 J/cm(2) UVA1 given in 29-40 fractions, and the effect was assessed by clinical examination and by high-resolution ultrasonography.
RESULTS
Complete clinical remission of MF was achieved in all cases.
CONCLUSIONS
This preliminary report indicates that UVA1 phototherapy might be an efficient treatment for early-stage MF.
背景
蕈样肉芽肿（MF）是原发性皮肤淋巴瘤中最常见的形式，其特征是 CD4+细胞的恶性增殖。补骨脂素加紫外线 A（PUVA）照射是治疗皮肤病变最常用的方法。然而，PUVA 存在对补骨脂素的不良反应风险和长期皮肤癌风险。长波紫外线 1（UVA1）可能是一种更安全的替代方法。
目的
评估 UVA1 光疗在早期 MF（T1-T2）患者中的疗效。
方法
4 例早期 MF 患者接受 1630-2710 J/cm² UVA1 治疗，分 29-40 次给予，通过临床检查和高分辨率超声评估疗效。
结果
所有患者的 MF 均达到完全临床缓解。
结论
本初步报告表明，UVA1 光疗可能是早期 MF 的有效治疗方法。
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