皮肤T细胞淋巴瘤的皮肤定向治疗
Skin Directed Therapy in Cutaneous T-Cell Lymphoma.
作者信息
Tarabadkar Erica S, Shinohara Michi M
机构信息
Division of Dermatology, University of Washington, Seattle, WA, United States.
出版信息
Front Oncol. 2019 Apr 11;9:260. doi: 10.3389/fonc.2019.00260. eCollection 2019.
Abstract
Skin directed therapies (SDTs) serve important roles in the treatment of early stage cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF), as well as managing symptoms and improving quality of life of all stages. There are now numerous options for topical therapies that demonstrate high response rates, particularly in early/limited MF. Phototherapy retains an important role in treating MF, with increasing data supporting efficacy and long-term safety of both UVB and PUVA as well as some newer/targeted methodologies. Radiation therapy, including localized radiation and total skin electron beam therapy, continues to be a cornerstone of therapy for all stages of MF.
摘要
皮肤定向疗法（SDTs）在早期皮肤T细胞淋巴瘤（CTCL）/蕈样肉芽肿（MF）的治疗中发挥着重要作用，同时也有助于控制各阶段的症状并提高生活质量。目前，局部治疗有多种选择，其有效率很高，尤其是在早期/局限性MF中。光疗在MF的治疗中仍发挥着重要作用，越来越多的数据支持UVB和PUVA以及一些更新的/靶向治疗方法的疗效和长期安全性。放射治疗，包括局部放射和全身皮肤电子束治疗，仍然是MF各阶段治疗的基石。
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