Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Israel.
Clin Exp Dermatol. 2012 Dec;37(8):850-6. doi: 10.1111/j.1365-2230.2012.04456.x. Epub 2012 Oct 22.
Different elements of the hypothalamic-pituitary-thyroid axis have been found to be implicated in the normal physiology of the human skin. Their effects on wound healing and hair growth in rats have been described previously. There is close homology between the thyroid hormone receptors in humans and guinea pigs.
To assess the effect of different doses of topical 3,3',5-triiodo-L-thyronine (T3) and recombinant human thyroid-stimulating hormone (TSH) on wound healing in guinea pigs.
Wounds were dressed every other day for 7 days, during which clinical measurements of the wounded areas were performed. Histological examination was performed at the end of the study.
Application of high and low concentrations of topical T3 but not TSH demonstrated a significant dose-dependent reduction in the wound surface area through a process of contraction. The main significant histological result was an increase in the hair-follicle count.
Topical T3 enhances wound healing in guinea pigs, primarily by wound contraction. As this is a critical stage in healing of chronic ulcers, topical T3 could be a useful treatment for wounds.
已经发现下丘脑-垂体-甲状腺轴的不同元素与人类皮肤的正常生理学有关。之前已经描述了它们对大鼠伤口愈合和毛发生长的影响。人类和豚鼠的甲状腺激素受体之间存在密切的同源性。
评估不同剂量的局部 3,3',5-三碘-L-甲状腺素 (T3) 和重组人促甲状腺激素 (TSH) 对豚鼠伤口愈合的影响。
每隔一天对伤口进行敷料处理 7 天，在此期间对受伤区域进行临床测量。研究结束时进行组织学检查。
应用高浓度和低浓度的局部 T3 但不是 TSH 通过收缩过程显著减少了伤口表面积。主要的显著组织学结果是毛囊计数增加。
局部 T3 可增强豚鼠的伤口愈合，主要通过伤口收缩。由于这是慢性溃疡愈合的关键阶段，因此局部 T3 可能是一种有用的伤口治疗方法。
