Mourouzis Iordanis, Politi Efstathia, Pantos Constantinos
Department of Pharmacology, University of Athens, 75 Mikras Asias Avenue, Goudi, 11527 Athens, Greece.
J Thyroid Res. 2013;2013:312104. doi: 10.1155/2013/312104. Epub 2013 Feb 25.
Although the role of thyroid hormone during embryonic development has long been recognized, its role later in adult life remains largely unknown. However, several lines of evidence show that thyroid hormone is crucial to the response to stress and to poststress recovery and repair. Along this line, TH administration in almost every tissue resulted in tissue repair after various injuries including ischemia, chemical insults, induction of inflammation, or exposure to radiation. This novel action may be of therapeutic relevance, and thyroid hormone may constitute a paradigm for pharmacologic-induced tissue repair/regeneration.
虽然甲状腺激素在胚胎发育过程中的作用早已为人所知，但其在成年后期的作用仍大多不为人知。然而，有几条证据表明，甲状腺激素对于应激反应以及应激后的恢复和修复至关重要。据此，在几乎每个组织中给予甲状腺激素都会在各种损伤后导致组织修复，这些损伤包括局部缺血、化学损伤、炎症诱导或辐射暴露。这种新作用可能具有治疗意义，并且甲状腺激素可能构成药物诱导组织修复/再生的一个范例。
