去铁胺对铁催化超氧化物形成羟基自由基及脂质过氧化的抑制作用。
Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine.
作者信息
Gutteridge J M, Richmond R, Halliwell B
出版信息
Biochem J. 1979 Nov 15;184(2):469-72. doi: 10.1042/bj1840469.
Abstract
The peroxidation of membrane phospholipids induced in vitro by ascorbic acid or by dialuric acid (hydroxybarbituric acid) does not occur in the absence of traces of metal ions. Peroxidation induced by adding iron salts to phospholipids can either be promoted or inhibited by the chelators EDTA, diethylenetriaminepenta-acetic acid and bathophenanthrolinesulphonate, depending on the ratio [chelator]/[iron salt]. The iron chelator desferrioxamine inhibits peroxidation at all concentrations tested, and it also inhibits the iron-catalysed formation of hydroxyl radicals (OH.) from superoxide (O2-.). Since desferrioxamine is approved for clinical use, it might prove a valuable tool in the treatment of inflammation, poisoning by autoxidizable molecules and radiation damage.
摘要
在体外，抗坏血酸或二羟基巴比妥酸（羟基巴比妥酸）诱导的膜磷脂过氧化反应，在没有痕量金属离子的情况下不会发生。向磷脂中添加铁盐所诱导的过氧化反应，可被螯合剂乙二胺四乙酸（EDTA）、二乙烯三胺五乙酸和4,7-二苯基-1,10-菲啰啉磺酸促进或抑制，这取决于[螯合剂]/[铁盐]的比例。铁螯合剂去铁胺在所有测试浓度下均能抑制过氧化反应，并且它还能抑制铁催化超氧化物（O₂⁻）形成羟基自由基（OH·）。由于去铁胺已被批准用于临床，它可能被证明是治疗炎症、可自氧化分子中毒和辐射损伤的一种有价值的工具。
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