全身 FDG-PET 和 FDG-PET/CT 对鼻咽癌 M 分期的准确性：系统评价和荟萃分析。
Accuracy of whole-body FDG-PET and FDG-PET/CT in M staging of nasopharyngeal carcinoma: a systematic review and meta-analysis.
机构信息
Department of Nuclear Medicine and PET Center, Changhua Christian Hospital, No. 135, Nanxiao Street, Changhua 500, Taiwan.
出版信息
Eur J Radiol. 2013 Feb;82(2):366-73. doi: 10.1016/j.ejrad.2012.06.031. Epub 2012 Oct 18.
BACKGROUND
A meta-analysis was conducted to evaluate the accuracy of whole-body positron emission tomography (PET) or PET/CT in M staging of nasopharyngeal carcinoma (NPC).
METHODS
Through a search of relevant English language studies from October 1996 to September 2011, pooled estimated sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, and summary receiver operating characteristic (SROC) curves of whole-body PET or PET/CT in M staging of NPC were calculated.
RESULTS
Three PET and 5 PET/CT studies were identified. The pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of FDG-PET or PET/CT were 0.83 (95% confidence interval [CI], 0.77-0.88), 0.97 (95% CI, 0.95-0.98), 23.38 (95% CI, 16.22-33.69), and 0.19 (95% CI, 0.13-0.25), respectively. The area under curve was 0.9764 and Q* index estimate was 0.9307 for FDG-PET or PET/CT.
CONCLUSION
Current evidence confirms the good diagnostic performance of the whole-body FDG-PET or PET/CT in M staging of NPC.
背景
进行了一项荟萃分析，以评估全身正电子发射断层扫描（PET）或 PET/CT 在鼻咽癌（NPC）分期中的准确性。
方法
通过搜索 1996 年 10 月至 2011 年 9 月相关的英文文献，计算全身 PET 或 PET/CT 在 NPC 分期中的汇总估计敏感性、特异性、阳性似然比、阴性似然比和综合受试者工作特征（SROC）曲线。
结果
确定了 3 项 PET 和 5 项 PET/CT 研究。FDG-PET 或 PET/CT 的汇总敏感性、特异性、阳性似然比和阴性似然比分别为 0.83（95%置信区间 [CI]，0.77-0.88）、0.97（95% CI，0.95-0.98）、23.38（95% CI，16.22-33.69）和 0.19（95% CI，0.13-0.25）。FDG-PET 或 PET/CT 的曲线下面积为 0.9764，Q* 指数估计值为 0.9307。
结论
目前的证据证实了全身 FDG-PET 或 PET/CT 在 NPC 分期中的良好诊断性能。
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