Suppr超能文献

人参可降低衰老大鼠的氧化应激并恢复其抗氧化能力。

Panax ginseng reduces oxidative stress and restores antioxidant capacity in aged rats.

机构信息

Department of Life Science, College of Biomedical and Health Science, Institute of Biomedical and Health Science, Konkuk University, Chungju-si 380-701, Korea.

出版信息

Nutr Res. 2012 Sep;32(9):718-26. doi: 10.1016/j.nutres.2012.08.005.

Abstract

Nutritional antioxidants interact with cells in an active mode, including retrieving and sparing one another, to diminish oxidative stress. However, the intracellular balance of prooxidants and antioxidants becomes unbalanced, favoring prooxidants during the aging process. One hypothesis is that an aging-associated increase in oxidative stress is the primary cause of aging. Hence, the research hypothesis for this study is that Korean red ginseng reduces oxidative stress in vivo. Therefore, we investigated the efficacy of Korean red ginseng water extract (GWE) in reducing aging-associated oxidative stress by measuring lipid peroxidation and antioxidant levels in older rats compared with young rats. We observed a significant increase in the markers for oxidative damage (eg, lipid peroxidation) and markers for vital organ damage (eg, aspartate aminotransferase, alanine aminotransferase, urea, and creatinine levels) in aged rats. The oxidative damage was accompanied by a significant decrease in enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase, and nonenzymatic antioxidants such as reduced glutathione, vitamin E, and vitamin C. Aged rats fed a diet supplemented with Korean red ginseng water extract had significantly less oxidative damage, possibly by enhancing the enzymatic and nonenzymatic antioxidants status. Our data suggest that consumption of Korean red ginseng reduces lipid peroxidation and restores antioxidant capacity by suppressing oxidative stress in rats.

摘要

营养抗氧化剂以活跃的方式与细胞相互作用,包括相互检索和保护,以减少氧化应激。然而,细胞内氧化剂和抗氧化剂的平衡会失衡,在衰老过程中有利于氧化剂。有一种假说认为,与衰老相关的氧化应激增加是衰老的主要原因。因此,本研究的研究假设是,红参能减轻体内的氧化应激。因此,我们通过测量老年大鼠与年轻大鼠相比的脂质过氧化和抗氧化剂水平,研究了红参水提取物(GWE)降低与衰老相关的氧化应激的功效。我们观察到,与年轻大鼠相比,老年大鼠的氧化损伤标志物(如脂质过氧化)和重要器官损伤标志物(如天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、尿素和肌酐水平)显著增加。氧化损伤伴随着超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和谷胱甘肽-S-转移酶等酶抗氧化剂以及还原型谷胱甘肽、维生素 E 和维生素 C 等非酶抗氧化剂显著减少。用红参水提取物补充饮食的老年大鼠的氧化损伤明显减少,这可能是通过增强酶和非酶抗氧化剂的状态来实现的。我们的数据表明,红参的摄入可以通过抑制大鼠的氧化应激来减少脂质过氧化并恢复抗氧化能力。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验