Public Health Computational and Operations Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States.
Vaccine. 2012 Dec 14;30(52):7443-6. doi: 10.1016/j.vaccine.2012.10.025. Epub 2012 Oct 19.
The recently licensed quadrivalent seasonal influenza vaccine (QIV) may provide better protection than the traditional trivalent influenza vaccine (TIV) as it includes one more influenza B strain. We developed a Monte Carlo simulation model to determine the economic value of a QIV compared to the TIV for 10 influenza seasons (1999-2009). The addition of the influenza B strain to convert the TIV into a QIV could result in substantial cost-savings to society (median of $3.1 billion) and third party payers (median of $292 million), even when the cost of QIV is significantly higher.
最近获得许可的四价季节性流感疫苗(QIV)可能比传统的三价流感疫苗(TIV)提供更好的保护,因为它包含了一种额外的乙型流感病毒株。我们开发了一个蒙特卡罗模拟模型,以确定与 TIV 相比,QIV 在 10 个流感季节(1999-2009 年)的经济价值。将 TIV 转换为 QIV 时添加乙型流感病毒株可以为社会(中位数为 31 亿美元)和第三方支付者(中位数为 2.92 亿美元)节省大量成本,即使 QIV 的成本显著更高。