Sutanto Henry, Waitupu Alief, Adytia Galih Januar, Fetarayani Deasy
Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya Indonesia.
Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Asia Pac Allergy. 2025 Sep;15(3):212-220. doi: 10.5415/apallergy.0000000000000195. Epub 2025 Mar 17.
Influenza remains a significant public health concern globally, including in Southeast Asia, where unique epidemiological patterns and year-round virus circulation necessitate tailored vaccination strategies. This article briefly explores the historical milestones of influenza vaccine development, tracing its evolution from early inactivated vaccines to modern formulations. It also examines the annual inclusion of specific virus strains in vaccines, detailing the codename system for strain identification. In tropical regions like Southeast Asia, the need for influenza vaccination is debated due to continuous exposure; however, evidence supports its efficacy in reducing disease burden. It also discusses World Health Organization guidelines for optimal vaccination timing based on regional influenza activity and identifies target populations, including high-risk groups, and considerations for broader immunization efforts. Addressing these factors can enhance vaccination strategies and reduce influenza's impact in Southeast Asia.
流感仍然是全球重大的公共卫生问题，在东南亚地区亦是如此。在东南亚，独特的流行病学模式和全年的病毒传播情况使得需要制定针对性的疫苗接种策略。本文简要探讨了流感疫苗研发的历史里程碑，追溯其从早期灭活疫苗到现代配方的演变过程。文章还研究了疫苗中特定病毒株的年度纳入情况，详细介绍了毒株识别的代号系统。在东南亚等热带地区，由于持续暴露于流感病毒，流感疫苗接种的必要性存在争议；然而，有证据支持其在减轻疾病负担方面的有效性。本文还讨论了世界卫生组织基于地区流感活动制定的最佳接种时机指南，并确定了目标人群，包括高危人群，以及更广泛免疫工作的注意事项。解决这些因素可以加强疫苗接种策略，减轻流感在东南亚的影响。
