由 C₂ 对称的 Pd-多齿 N-杂环卡宾配合物催化的铃木-宫浦反应。
Suzuki-Miyaura reactions catalyzed by C₂-symmetric Pd-multi-dentate N-heterocyclic carbene complexes.
机构信息
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
出版信息
Molecules. 2012 Oct 16;17(10):12121-39. doi: 10.3390/molecules171012121.
Abstract
Suzuki-Miyaura coupling reactions are promoted by Pd complexes ligated with C₂-symmetric multi-dentate N-heterocyclic carbenes derived in situ from Pd(OAc)₂ and imidazolium salts. Good to excellent yields were obtained for aryl bromides as substrates. Turnover numbers of up to 10⁵ could be achieved with 5 × 10⁻⁴ mol% of Pd(OAc)₂/1 × 10⁻³ mol% NHC precatalyst in 24 h.
摘要
铃木-宫浦偶联反应是由 Pd 配合物促进的，该配合物通过 Pd(OAc)₂ 和咪唑鎓盐原位衍生的 C₂ 对称多齿 N-杂环卡宾配体。芳基溴化物作为底物时，可获得良好至优异的产率。在 24 小时内，使用 5×10⁻⁴mol%的 Pd(OAc)₂/1×10⁻³mol%的 NHC 前催化剂，可实现高达 10⁵的转化率数。
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