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急性脑梗死致认知障碍患者扩散峰度成像检测到的微观结构改变

Altered Microstructural Changes Detected by Diffusion Kurtosis Imaging in Patients With Cognitive Impairment After Acute Cerebral Infarction.

作者信息

Fan Liting, Ibrahim Fatima Elzahra E M, Chu Xiaoqi, Fu Yu, Yan Hongting, Wu Zheng, Tao Chunmei, Chen Xuejing, Ma Yue, Guo Yunchu, Dong Yang, Yang Chao, Ge Yusong

机构信息

Second Affiliated Hospital of Dalian Medical University, Dalian, China.

出版信息

Front Neurol. 2022 Feb 28;13:802357. doi: 10.3389/fneur.2022.802357. eCollection 2022.

DOI:10.3389/fneur.2022.802357
PMID:35295835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8918512/
Abstract

OBJECTIVE

To detect the microstructural changes in patients with cognitive impairment after acute cerebral infarction using diffusion kurtosis imaging (DKI).

MATERIALS AND METHODS

A total of 70 patients with acute cerebral infarction were divided into two groups: 35 patients with cognitive impairment (VCI group), and 35 patients without cognitive impairment (N-VCI group), according to mini-mental state examination (MMSE) score. Healthy individuals ( = 36) were selected as the normal control (NORM) group. DKI parameters from 28 different brain regions of interest (ROIs) were selected, measured, and compared.

RESULTS

VCI group patients had significantly higher mean diffusion (MD) and significantly lower mean kurtosis (MK) values in most ROIs than those in the N-VCI and NORM groups. DKI parameters in some ROIs correlated significantly with MMSE score. The splenium of corpus callosum MD was most correlated with MMSE score, the correlation coefficient was -0.652, and this parameter had good ability to distinguish patients with VCI from healthy controls; at the optimal cut-off MD value (0.9915), sensitivity was 91.4%, specificity 100%, and the area under the curve value 0.964.

CONCLUSIONS

Pathological changes in some brain regions may underlie cognitive impairment after acute cerebral infarction, especially the splenium of corpus callosum. These preliminary results suggest that, in patients with VCI, DKI may be useful for assessing microstructural tissue damage.

摘要

目的

采用扩散峰度成像（DKI）检测急性脑梗死患者认知功能障碍后的微观结构变化。

材料与方法

根据简易精神状态检查表（MMSE）评分，将70例急性脑梗死患者分为两组：35例有认知功能障碍的患者（VCI组）和35例无认知功能障碍的患者（N-VCI组）。选取健康个体（n = 36）作为正常对照组（NORM组）。选取、测量并比较28个不同脑感兴趣区（ROI）的DKI参数。

结果

VCI组患者多数ROI的平均扩散率（MD）显著高于N-VCI组和NORM组，平均峰度（MK）值显著低于这两组。部分ROI的DKI参数与MMSE评分显著相关。胼胝体压部MD与MMSE评分的相关性最高，相关系数为-0.652，该参数区分VCI患者与健康对照的能力良好；在最佳截断MD值（0.9915）时，敏感度为91.4%，特异度为100%，曲线下面积值为0.964。

结论

某些脑区的病理改变可能是急性脑梗死患者认知功能障碍的基础，尤其是胼胝体压部。这些初步结果表明，对于VCI患者，DKI可能有助于评估微观结构组织损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/1947fdfc3164/fneur-13-802357-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/24ff8db6a3c8/fneur-13-802357-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/78144bd0ab37/fneur-13-802357-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/87a18679ffb3/fneur-13-802357-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/f697b31dd212/fneur-13-802357-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/869babbdad64/fneur-13-802357-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/1947fdfc3164/fneur-13-802357-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/24ff8db6a3c8/fneur-13-802357-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/78144bd0ab37/fneur-13-802357-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/87a18679ffb3/fneur-13-802357-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/f697b31dd212/fneur-13-802357-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/869babbdad64/fneur-13-802357-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/8918512/1947fdfc3164/fneur-13-802357-g0006.jpg

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