Brenes Robert A, Bear Mackenzie, Jadlowiec Caroline, Goodwin Matthew, Hashim Peter, Protack Clinton D, Ziegler Kenneth R, Li Xin, Model Lynn S, Lv Wei, Collins Michael J, Dardik Alan
Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520-8089, USA.
Vascular. 2012 Dec;20(6):360-8. doi: 10.1258/vasc.2011.201205. Epub 2012 Oct 19.
Alternative therapies are currently being developed to treat patients with chronic limb ischemia who are unable to be revascularized in order to avoid amputation. Cell-based therapy using mononuclear cells is gaining attention as many clinical trials are currently underway. We review cell differentiation along with the different potential cell sources for use in therapeutic angiogenesis.
目前正在开发替代疗法,用于治疗无法进行血管重建以避免截肢的慢性肢体缺血患者。随着许多临床试验正在进行,使用单核细胞的细胞疗法正受到关注。我们回顾了细胞分化以及用于治疗性血管生成的不同潜在细胞来源。