用于缺血治疗的包裹生物工程间充质干细胞的超分子水凝胶。
Supramolecular hydrogels encapsulating bioengineered mesenchymal stem cells for ischemic therapy.
作者信息
Hwang Byung Woo, Kim Young-Eun, Kim Mungu, Han Seulgi, Bok Seoyeon, Park Kyeng Min, Shrinidhi Annadka, Kim Ki Su, Ahn G-One, Hahn Sei Kwang
机构信息
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH) 77 Cheongam-ro Pohang 37673 Korea.
Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH) 77 Cheongam-ro Pohang 37673 Korea.
出版信息
RSC Adv. 2018 May 22;8(34):18771-18775. doi: 10.1039/c8ra00464a.
We developed supramolecular hyaluronate (HA) hydrogels to encapsulate genetically engineered mesenchymal stem cells (MSCs) for the treatment of limb ischemia. angiogenic factors could be produced stably by the bioengineered MSCs (BMSCs) within the supramolecular hydrogels showing effective vascular repair and enhanced blood perfusion.
我们研发了超分子透明质酸（HA）水凝胶来包裹基因工程化间充质干细胞（MSCs），用于治疗肢体缺血。在超分子水凝胶内，生物工程化间充质干细胞（BMSCs）能够稳定产生血管生成因子，显示出有效的血管修复和增强的血液灌注。
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