Maimaiti Rena, Zhang Yuexin, Pan Kejun, Wubuli Maimaiti, Andersson Rune
Department of Prevention and Care, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
J Int Assoc Provid AIDS Care. 2013 Jan-Feb;12(1):58-61. doi: 10.1177/1545109712446176. Epub 2012 Oct 18.
To analyze the epidemiology and outcome for patients with HIV coinfected with hepatitis in comparison with monoinfected patients.
At the First Affiliated Hospital at Xinjiang Medical University in Urumqi, China, 395 patients were diagnosed with HIV between 2001 and 2010. The main routes of transmission were sexual (30%) and intravenous drug use (33%). The patient records were studied retrospectively.
A total of 135 patients had markers of viral hepatitis (34.2%). Abnormal liver function was seen among 48.9% of these patients. Hepatitis B surface antigen was positive in 24 patients (6.1%), with 15 (3.8%) being hepatitis B virus (HBV)-DNA positive, none on tenofovir treatment, because it is still not provided free in Xinjiang. Hepatitis C antibodies were found in 98 patients (24.8%), 46 (11.6%) were hepatitis C virus (HCV)-RNA positive. Only 1 patient had been treated with interferon and ribavirin. Both HBV and HCV were found in 13 (3.3%) of the patients.
Nearly half of the HIV patients in Urumqi had markers of hepatitis. Only antiretroviral treatment is provided free, and most of the patients cannot afford the hepatitis treatment they need, which has to be addressed in the treatment programs.
分析合并感染肝炎的HIV患者的流行病学情况及预后，并与单一感染患者进行比较。
在中国乌鲁木齐的新疆医科大学第一附属医院，2001年至2010年间有395例患者被诊断为HIV感染。主要传播途径为性传播（30%）和静脉吸毒（33%）。对患者记录进行回顾性研究。
共有135例患者有病毒性肝炎标志物（34.2%）。这些患者中48.9%肝功能异常。24例患者乙肝表面抗原阳性（6.1%），其中15例（3.8%）乙肝病毒（HBV）-DNA阳性，接受替诺福韦治疗的患者中无一例阳性，因为在新疆替诺福韦仍未免费提供。98例患者丙肝抗体阳性（24.8%），46例（11.6%）丙肝病毒（HCV）-RNA阳性。只有1例患者接受过干扰素和利巴韦林治疗。13例（3.3%）患者同时感染HBV和HCV。
乌鲁木齐近一半的HIV患者有肝炎标志物。目前仅免费提供抗逆转录病毒治疗，大多数患者负担不起所需的肝炎治疗费用，这一问题必须在治疗方案中加以解决。
