Balonov M I, Shrimpton P C
Institute of Radiation Hygiene, 8 Mira St, 197046 St. Petersburg, Russia.
Ann ICRP. 2012 Oct-Dec;41(3-4):129-41. doi: 10.1016/j.icrp.2012.06.002. Epub 2012 Aug 22.
The radiation risks from a range of medical x-ray examinations (radiography, fluoroscopy, and computed tomography) were assessed as a function of the age and sex of the patient using risk models described in Publication 103 (ICRP, 2007) and UNSCEAR (2006, Annex A). Such estimates of risk based on typical organ doses were compared with those derived from effective doses using the International Commission on Radiological Protection's nominal risk coefficients. Methodologically similar but not identical dose and risk calculations were performed independently at the Institute of Radiation Hygiene (Russia) and the Health Protection Agency (UK), and led to similar conclusions. The radiogenic risk of stochastic health effects following various x-ray procedures varied significantly with the patient's age and sex, but to differing degrees depending on which body organs were irradiated. In general, the risks of radiation-induced stochastic health effects in children are estimated to be higher (by a factor of ≤ 4) than in adults, and risks in senior patients are lower by a factor of ≥ 10 relative to younger people. If risks are assessed on the basis of effective dose, they are underestimated for children of both sexes by a factor of ≤ 4. This approach overestimates risks by a factor of ≤ 3 for adults and about an order of magnitude for senior patients. The significant sex and age dependence of radiogenic risk for different cancer types is an important consideration for radiologists when planning x-ray examinations. Whereas effective dose was not intended to provide a measure of risk associated with such examinations, it may be sufficient to make simple adjustments to the nominal risk per unit effective dose to account for age and sex differences.
利用第103号出版物(国际放射防护委员会,2007年)以及联合国原子辐射效应科学委员会(2006年,附件A)中描述的风险模型,根据患者的年龄和性别,评估了一系列医学X射线检查(放射摄影、荧光透视和计算机断层扫描)的辐射风险。基于典型器官剂量的此类风险估计值,与使用国际放射防护委员会的标称风险系数从有效剂量得出的估计值进行了比较。俄罗斯辐射卫生研究所和英国健康保护局分别独立进行了方法上相似但不完全相同的剂量和风险计算,得出了相似的结论。各种X射线检查后随机健康效应的辐射致癌风险,随患者的年龄和性别有显著差异,但因受照射的身体器官不同而程度各异。一般而言,估计儿童辐射诱发随机健康效应的风险比成人高(最高达4倍),老年患者的风险相对于年轻人则低至10倍以上。如果根据有效剂量评估风险,两性儿童的风险被低估最高达4倍。这种方法对成人风险的高估最高达3倍,对老年患者则高估约一个数量级。不同癌症类型的辐射致癌风险对性别和年龄的显著依赖性,是放射科医生在规划X射线检查时的一个重要考虑因素。虽然有效剂量并非旨在提供与此类检查相关的风险衡量指标,但对每单位有效剂量的标称风险进行简单调整以考虑年龄和性别差异可能就足够了。