Legault-Poisson S, Jolivet J, Poisson R, Beretta-Piccoli M, Band P R
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1839-41.
A postmenopausal breast cancer patient with a measurable lung metastasis was treated with tamoxifen. The tumor doubling time of the pulmonary lesion was 140 days during spontaneous growth and 52 days during tamoxifen therapy, an almost threefold increase in tumor growth rate. This stimulation persisted fro 1 month after discontinuation of tamoxifen and was followed thereafter by a withdrawal regression lasting greater than 6 months. Awareness of the possible tumor growth enhancement with tamoxifen is of importance especially in view of its prolonged activity. Hormone withdrawal regression may occur following tamoxifen therapy, and a sufficient time interval should therefore elapse between cessation of tamoxifen and initiation of other therapeutic modalities.
一名患有可测量肺转移灶的绝经后乳腺癌患者接受了他莫昔芬治疗。肺部病变在自然生长期间的肿瘤倍增时间为140天，在他莫昔芬治疗期间为52天，肿瘤生长速率几乎增加了两倍。这种刺激在停用他莫昔芬后持续了1个月，随后出现了持续超过6个月的撤药后消退。鉴于他莫昔芬的作用时间较长，认识到其可能增强肿瘤生长的情况尤为重要。他莫昔芬治疗后可能会出现激素撤药后消退，因此在停用他莫昔芬和开始其他治疗方式之间应留出足够的时间间隔。
