Janicek M J, Shaffer K
Department of Radiology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Skeletal Radiol. 1995 Nov;24(8):597-600. doi: 10.1007/BF00204859.
To determine whether temporal changes in scintigraphic and bone radiographic findings have prognostic significance in patients with skeletal metastases from breast cancer.
Clinical information and films were retrospectively reviewed in 101 randomly selected patients with skeletal metastases. Images from sequential bond scans and bone radiographs were correlated with survival after detection of the metastases.
Time to detection of skeletal metastases and the length of time for which patients were classified as radiologically stable after development of skeletal metastases correlated with survival (r = 0.843; r = 0.821, respectively). Failure to develop a radiographically and scintigraphically stable pattern after treatment was associated with significantly decreased survival compared with the rest of the patients (mean survival 2.1 +/- 1.3 years vs 4.3 +/- 2.3 years; p < 0.001). Scintigraphic regression of metastases was associated with significant survival benefit and longer stabilization of disease compared to all other patterns (mean survival 5.0 +/- 2.7 years of regressive disease vs 3.7 +/- 1.9 years for stable disease and 2.2 +/- 1.3 years for progressive disease; p < 0.001).
Sequential scintigraphic and radiographic imaging is useful in breast cancer patients not only for detection of metastases and monitoring of treatment effect, but also because these studies provide valuable prognostic information.
确定闪烁扫描和骨放射影像学检查结果的时间变化对乳腺癌骨转移患者是否具有预后意义。
对101例随机选取的骨转移患者的临床信息和影像资料进行回顾性分析。将连续骨扫描和骨放射影像的图像与转移灶发现后的生存率进行关联分析。
骨转移灶的发现时间以及骨转移发生后患者被分类为放射学稳定的时间长度与生存率相关（r分别为0.843和0.821）。与其他患者相比，治疗后未形成放射学和闪烁扫描学稳定模式的患者生存率显著降低（平均生存期2.1±1.3年对4.3±2.3年；p<0.001）。与所有其他模式相比，转移灶的闪烁扫描消退与显著的生存获益和更长的疾病稳定期相关（消退性疾病的平均生存期5.0±2.7年，稳定疾病为3.7±1.9年，进展性疾病为2.2±1.3年；p<0.001）。
连续的闪烁扫描和放射影像学检查不仅有助于乳腺癌患者转移灶的检测和治疗效果的监测，还因为这些研究可提供有价值的预后信息。
