Di Ninni Paola, Bérubé-Lauzière Yves, Mercatelli Luca, Sani Elisa, Martelli Fabrizio
Dipartimento di Fisica e Astronomia dell'Università degli Studi di Firenze, Firenze, Italy.
Appl Opt. 2012 Oct 20;51(30):7176-82. doi: 10.1364/AO.51.007176.
Intralipid 20% was recently suggested as a diffusive reference standard for tissue simulating phantoms. In this work, we extend previously obtained results to other fat emulsions, specifically Intralipid 10%, Intralipid 30%, Lipovenoes 10%, Lipovenoes 10% PhosphoLipid Reduced, Lipovenoes 20%, Lipofundin S 10%, and Lipofundin S 20%. Of particular importance for practical applications, our measurements carried out at a wavelength of 751 nm show the following features. First, these products show high stability and small batch-to-batch variations in their diffusive optical properties, similar to Intralipid 20%. Second, the absorption coefficient of Intralipid, Lipovenoes, and Lipofundin S are very similar and their measured values are within the experimental errors; moreover the reduced scattering coefficient of Intralipid 20%, Lipovenoes 20%, and Lipofundin S 20% are similar and their measured values are within 5%. Third, the reduced scattering coefficient of Intralipid 10% and Intralipid 30% can be scaled from that of Intralipid 20% with an error of 9% and 2%, respectively. A similar scaling property is valid for Lipovenoes and Lipofundin S. We have verified that this scaling property depends on the composition of the fat emulsions: If the ingredients exactly scale with the concentration then the reduced scattering coefficient almost exactly scale as well.
20% 英脱利匹特最近被提议作为组织模拟体模的扩散参考标准。在这项工作中,我们将先前获得的结果扩展到其他脂肪乳剂,具体包括10% 英脱利匹特、30% 英脱利匹特、10% 力保肪宁、低磷脂10% 力保肪宁、20% 力保肪宁、10% 英托利孚、20% 英托利孚。对于实际应用特别重要的是,我们在751 nm波长下进行的测量显示出以下特征。首先,这些产品在其扩散光学特性方面表现出高稳定性和小的批次间差异,类似于20% 英脱利匹特。其次,英脱利匹特、力保肪宁和英托利孚的吸收系数非常相似,其测量值在实验误差范围内;此外,20% 英脱利匹特、20% 力保肪宁和20% 英托利孚的约化散射系数相似,其测量值在5% 以内。第三,10% 英脱利匹特和30% 英脱利匹特的约化散射系数可以分别从20% 英脱利匹特的约化散射系数按比例缩放,误差分别为9% 和2%。类似的缩放特性对力保肪宁和英托利孚也有效。我们已经验证了这种缩放特性取决于脂肪乳剂的成分:如果成分与浓度精确成比例,那么约化散射系数几乎也会精确成比例。