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Pharmacogenetics and other reasons why drugs can fail in pregnancy: higher dose or different drug?药物遗传学及其他导致药物在孕期失败的原因：更高剂量还是不同药物？
Obstet Gynecol. 2012 Nov;120(5):1176-9. doi: 10.1097/aog.0b013e3182698538.
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The comparison of side effects of methyldopa, amlodipine, and metoprolol in pregnant women with chronic hypertension.比较慢性高血压孕妇使用甲基多巴、氨氯地平和美托洛尔的副作用。
Hypertens Pregnancy. 2020 Aug;39(3):314-318. doi: 10.1080/10641955.2020.1766489. Epub 2020 May 18.
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Effect of pregnancy on the pharmacokinetics of antihypertensive drugs.妊娠对抗高血压药物药代动力学的影响。
Clin Pharmacokinet. 2009;48(3):159-68. doi: 10.2165/00003088-200948030-00002.
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The relevance of CYP2D6 genetic polymorphism on chronic metoprolol therapy in cardiovascular patients.CYP2D6基因多态性对心血管疾病患者美托洛尔长期治疗的相关性。
J Clin Pharm Ther. 2006 Feb;31(1):99-109. doi: 10.1111/j.1365-2710.2006.00699.x.
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Effects of polymorphism of the beta(1) adrenoreceptor and CYP2D6 on the therapeutic effects of metoprolol.β1肾上腺素能受体和CYP2D6基因多态性对美托洛尔治疗效果的影响。
J Int Med Res. 2008 Nov-Dec;36(6):1354-62. doi: 10.1177/147323000803600624.
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Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions.利培酮治疗的高血压患者治疗中的药代动力学考量——关于临床相关的CYP2D6相互作用的思考
J Psychopharmacol. 2016 Aug;30(8):803-9. doi: 10.1177/0269881116650390. Epub 2016 May 31.
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Is personalized medicine achievable in obstetrics?个性化医疗在产科可行吗？
Semin Perinatol. 2014 Dec;38(8):534-40. doi: 10.1053/j.semperi.2014.08.017. Epub 2014 Oct 3.
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Pharmacogenetics of drug-drug interaction and drug-drug-gene interaction: a systematic review on CYP2C9, CYP2C19 and CYP2D6.药物相互作用和药物-药物-基因相互作用的药物遗传学：关于CYP2C9、CYP2C19和CYP2D6的系统评价
Pharmacogenomics. 2017 May;18(7):701-739. doi: 10.2217/pgs-2017-0194. Epub 2017 May 8.
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Influence of chronic renal failure on stereoselective metoprolol metabolism in hypertensive patients.慢性肾衰竭对高血压患者美托洛尔立体选择性代谢的影响。
J Clin Pharmacol. 2005 Dec;45(12):1422-33. doi: 10.1177/0091270005281816.
引用本文的文献
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Pharmacogenomic Testing In Pediatrics: Navigating The Ethical, Social, And Legal Challenges.儿科药物基因组学检测：应对伦理、社会和法律挑战
Pharmgenomics Pers Med. 2019 Oct 14;12:273-285. doi: 10.2147/PGPM.S179172. eCollection 2019.
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Use of Antipsychotics During Pregnancy: Pregnant Women Get Sick-Sick Women Get Pregnant.孕期使用抗精神病药物：孕妇患病——患病女性怀孕。
JAMA Psychiatry. 2016 Sep 1;73(9):901-3. doi: 10.1001/jamapsychiatry.2016.1538.
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Use of medication for cardiovascular disease during pregnancy.妊娠期心血管疾病药物治疗。
Nat Rev Cardiol. 2015 Dec;12(12):718-29. doi: 10.1038/nrcardio.2015.172.
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Short-term tocolytics for preterm delivery - current perspectives.早产的短期宫缩抑制剂——当前观点
Int J Womens Health. 2014 Mar 27;6:343-9. doi: 10.2147/IJWH.S44048. eCollection 2014.
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Pharmacogenetics and individualizing drug treatment during pregnancy.药物遗传学与妊娠期个体化药物治疗。
Pharmacogenomics. 2014 Jan;15(1):69-78. doi: 10.2217/pgs.13.228.
本文引用的文献
1
We don't know what we don't study: the case for research on medication effects in pregnancy.我们不研究未知：孕期药物影响研究的必要性。
Am J Med Genet C Semin Med Genet. 2011 Aug 15;157C(3):247-50. doi: 10.1002/ajmg.c.30309. Epub 2011 Jul 15.
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Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy.临床药物基因组学实施联盟 CYP2C19（细胞色素 P450-2C19）基因型和氯吡格雷治疗指南。
Clin Pharmacol Ther. 2011 Aug;90(2):328-32. doi: 10.1038/clpt.2011.132. Epub 2011 Jun 29.
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Pharmacotherapy and pregnancy: highlights from the Third International Conference for Individualized Pharmacotherapy in Pregnancy.药物治疗与妊娠：第三届个体化药物治疗妊娠国际会议要点。
Clin Transl Sci. 2011 Jun;4(3):204-9. doi: 10.1111/j.1752-8062.2011.00280.x.
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Pharmacokinetics of oseltamivir among pregnant and nonpregnant women.奥司他韦在孕妇和非孕妇中的药代动力学。
Am J Obstet Gynecol. 2011 Jun;204(6 Suppl 1):S84-8. doi: 10.1016/j.ajog.2011.03.002. Epub 2011 Mar 9.
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Drug therapy of cancer.癌症的药物治疗。
Eur J Clin Pharmacol. 2011 May;67(5):437-47. doi: 10.1007/s00228-011-1011-x. Epub 2011 Feb 20.
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VKORC1, CYP2C9 and CYP4F2 genetic-based algorithm for warfarin dosing: an Italian retrospective study.VKORC1、CYP2C9 和 CYP4F2 基因算法在华法林剂量中的应用：一项意大利回顾性研究。
Pharmacogenomics. 2011 Jan;12(1):15-25. doi: 10.2217/pgs.10.162.
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Testing of VKORC1 and CYP2C9 alleles to guide warfarin dosing. Test category: pharmacogenomic (treatment).检测维生素K环氧化物还原酶复合体亚单位1（VKORC1）和细胞色素P450 2C9（CYP2C9）等位基因以指导华法林剂量调整。检测类别：药物基因组学（治疗）。
PLoS Curr. 2010 Sep 14;2:RRN1155. doi: 10.1371/currents.RRN1155.
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Pharmacogenetics of drug hypersensitivity.药物过敏的药物遗传学。
Pharmacogenomics. 2010 Jul;11(7):973-87. doi: 10.2217/pgs.10.77.
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CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance.CYP2D6 介导体外可乐定的 4-羟化作用：提示妊娠引起可乐定清除率的变化。
Drug Metab Dispos. 2010 Sep;38(9):1393-6. doi: 10.1124/dmd.110.033878. Epub 2010 Jun 22.
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Pharmacokinetics of metformin during pregnancy.妊娠期间二甲双胍的药代动力学。
Drug Metab Dispos. 2010 May;38(5):833-40. doi: 10.1124/dmd.109.031245. Epub 2010 Jan 29.
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