药物遗传学与妊娠期个体化药物治疗。
Pharmacogenetics and individualizing drug treatment during pregnancy.
机构信息
Department of OB/GYN, Indiana University School of Medicine, 1001 W. 10th Street, F5102, Indianapolis, IN 46202, USA.
出版信息
Pharmacogenomics. 2014 Jan;15(1):69-78. doi: 10.2217/pgs.13.228.
Abstract
Pharmacogenetics as a tool to aid clinicians implement individualized pharmacotherapy is utilized in some areas of medicine. Pharmacogenetics in pregnancy is still a developing field. However, there are several areas of obstetric therapeutics where data are emerging that give glimpses into future therapeutic possibilities. These include opioid pain management, antihypertensive therapy, antidepressant medications, preterm labor tocolytics, antenatal corticosteroids and drugs for nausea and vomiting of pregnancy, to name a few. More data are needed to populate the therapeutic models and to truly determine if pharmacogenetics will aid in individualizing pharmacotherapy in pregnancy. The objective of this review is to summarize current data and highlight research needs.
摘要
药物遗传学作为一种帮助临床医生实施个体化药物治疗的工具，已在医学的一些领域得到应用。妊娠期药物遗传学仍然是一个不断发展的领域。然而，在产科治疗的几个领域，正在出现一些数据，这些数据为未来的治疗可能性提供了一些线索。其中包括阿片类药物疼痛管理、抗高血压治疗、抗抑郁药物、早产保胎治疗、产前皮质激素以及治疗妊娠恶心和呕吐的药物等。需要更多的数据来填充治疗模型，并真正确定药物遗传学是否有助于实现妊娠期药物治疗的个体化。本综述的目的是总结当前的数据并突出研究需求。
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