Department of Internal Medicine, National Medical Center, Seoul, Korea.
J Korean Med Sci. 2012 Oct;27(10):1143-6. doi: 10.3346/jkms.2012.27.10.1143. Epub 2012 Oct 2.
Much controversy surrounds the issue of whether HIV infection is a risk factor for developing multidrug-resistant tuberculosis (MDR-TB). In this study, we evaluated the prevalence of and risk factors for MDR-TB in HIV-infected patients at the National Medical Center of Korea. We reviewed the medical records of HIV/TB co-infected patients from January 2005 to May 2011; the drug susceptibility profiles were available for 55 patients. Of these, 32.7% had MDR-TB, which was approximately 3.6 times higher than the prevalence among the general population. Additionally, there were more additional AIDS-defining clinical illnesses in the MDR-TB group than in the non-MDR-TB group (27.8% vs 5.4%, P = 0.032). These results suggest that HIV infection and HIV-related immunosuppresion may contribute to the development of MDR-TB.
围绕 HIV 感染是否是耐多药结核病（MDR-TB）发展的危险因素，存在着诸多争议。在本研究中，我们评估了韩国国立医疗中心的 HIV 感染患者中 MDR-TB 的流行率和危险因素。我们回顾了 2005 年 1 月至 2011 年 5 月期间 HIV/TB 合并感染患者的病历；其中 55 例患者的药敏谱可用。在这些患者中，32.7%患有 MDR-TB，这一比例大约是普通人群的 3.6 倍。此外，MDR-TB 组比非 MDR-TB 组有更多的艾滋病定义性临床疾病（27.8% vs 5.4%，P = 0.032）。这些结果表明，HIV 感染和 HIV 相关的免疫抑制可能导致 MDR-TB 的发生。
