艾滋病毒和结核病：致命的人类综合征。
HIV and tuberculosis: a deadly human syndemic.
机构信息
Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016 USA.
出版信息
Clin Microbiol Rev. 2011 Apr;24(2):351-76. doi: 10.1128/CMR.00042-10.
Abstract
A syndemic is defined as the convergence of two or more diseases that act synergistically to magnify the burden of disease. The intersection and syndemic interaction between the human immunodeficiency virus (HIV) and tuberculosis (TB) epidemics have had deadly consequences around the world. Without adequate control of the TB-HIV syndemic, the long-term TB elimination target set for 2050 will not be reached. There is an urgent need for additional resources and novel approaches for the diagnosis, treatment, and prevention of both HIV and TB. Moreover, multidisciplinary approaches that consider HIV and TB together, rather than as separate problems and diseases, will be necessary to prevent further worsening of the HIV-TB syndemic. This review examines current knowledge of the state and impact of the HIV-TB syndemic and reviews the epidemiological, clinical, cellular, and molecular interactions between HIV and TB.
摘要
综合征被定义为两种或多种疾病的同时发生，这些疾病协同作用，使疾病负担加剧。人类免疫缺陷病毒（HIV）和结核病（TB）流行之间的交叉和综合征相互作用在全球范围内造成了致命的后果。如果不能充分控制结核-艾滋病毒综合征，到 2050 年设定的长期结核病消除目标将无法实现。目前迫切需要更多的资源和新方法来诊断、治疗和预防 HIV 和结核病。此外，需要采取多学科方法，将 HIV 和结核病视为一个整体，而不是分开的问题和疾病，以防止艾滋病毒-结核综合征进一步恶化。这篇综述考察了艾滋病毒-结核综合征的现状和影响，并回顾了 HIV 和结核之间的流行病学、临床、细胞和分子相互作用。
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