钒的遗传毒性评估。

An assessment of the genotoxicity of vanadium.

作者信息

Owusu-Yaw J, Cohen M D, Fernando S Y, Wei C I

机构信息

Food Science and Human Nutrition Department, University of Florida, Gainesville 32611.

出版信息

Toxicol Lett. 1990 Feb;50(2-3):327-36. doi: 10.1016/0378-4274(90)90026-i.

DOI:10.1016/0378-4274(90)90026-i

PMID:2309250

Abstract

The activities of vanadium oxide (V2O3), vanadyl sulfate (VOSO4) and ammonium metavanadate (NH4VO3) in inducing sister chromatid exchange (SCE) and chromosomal aberrations (CAb) were assayed in Chinese hamster ovary cells. The toxic concentrations (TC50) for these compounds were found to be 25, 23 and 16 micrograms elemental vanadium/ml, respectively. At does 1/50-1/4 TC50, vanadium compounds were able to induce significant increases (P less than 0.01) in the SCE frequency with or without the addition of rat hepatic S9 mix. These compounds also induced CAb in the cells at doses closely equivalent to the TC50.

摘要

在中国仓鼠卵巢细胞中检测了氧化钒（V2O3）、硫酸氧钒（VOSO4）和偏钒酸铵（NH4VO3）诱导姐妹染色单体交换（SCE）和染色体畸变（CAb）的活性。发现这些化合物的毒性浓度（TC50）分别为25、23和16微克元素钒/毫升。在剂量为1/50 - 1/4 TC50时，无论是否添加大鼠肝脏S9混合物，钒化合物都能使SCE频率显著增加（P < 0.01）。这些化合物在与TC50紧密相当的剂量下也能诱导细胞发生CAb。