Chromosomal aberrations, sister-chromatid exchanges, cell-cycle kinetics and satellite associations in human lymphocyte cultures exposed to vanadium pentoxide.

Treatment of human lymphocytes with vanadium pentoxide (V2O5) was not found to increase the frequency of structural chromosomal aberrations (CA) and sister-chromatid exchanges (SCE). However, V2O5 significantly increased polyploid cell frequency; also, the mitotic index (MI) was significantly decreased, and the average generation time (AGT) was significantly increased. Finally, the frequency of cells with satellite associations (SA), the frequency of SA per cell, and the frequency of chromosomes associated increased in treated cultures.