Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada, K1N 6N5.
Org Lett. 2012 Nov 2;14(21):5602-5. doi: 10.1021/ol302725x. Epub 2012 Oct 23.
Palladium-catalyzed oxidative cyclocarbonylation of 2-vinylphenols constitutes a simple, direct method for the synthesis of coumarins. The reaction conditions, employing low pressures of CO, and air or 1,4- benzoquinone as the oxidant, are attractive in terms of environmental considerations and operational simplicity. Coumarins with a variety of functional groups were prepared in yields up to 85%.
钯催化 2-乙烯基苯酚的氧化环羰基化反应是一种合成香豆素的简单、直接的方法。该反应条件采用低压 CO 和空气或 1,4-苯醌作为氧化剂，从环境考虑和操作简单性方面来看具有吸引力。具有各种官能团的香豆素的产率高达 85%。
