Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Aust N Z J Psychiatry. 2013 Mar;47(3):271-5. doi: 10.1177/0004867412465022. Epub 2012 Oct 23.
To compare the therapeutic effects of vitamin D3 plus fluoxetine and fluoxetine alone in patients with major depressive disorder.
In the present double-blind, randomized, placebo-controlled trial, 42 patients with a diagnosis of major depressive disorder based on DSM-IV criteria were randomly assigned into two groups to receive daily either 1500 IU vitamin D3 plus 20 mg fluoxetine or fluoxetine alone for 8 weeks. Depression severity was assessed at 2-week intervals using the 24-item Hamilton Depression Rating Scale (HDRS) as a primary outcome measure and the 21-item Beck Depression Inventory (BDI) as a secondary outcome measure. Serum 25(OH) vitamin D was measured at baseline and after intervention.
Forty patients completed the trial. A two-way repeated-measures analysis of variance showed that depression severity based on HDRS and BDI decreased significantly after intervention, with a significant difference between the two groups. The vitamin D + fluoxetine combination was significantly better than fluoxetine alone from the fourth week of treatment.
In the present 8-week trial, the vitamin D + fluoxetine combination was superior to fluoxetine alone in controlling depressive symptoms.
比较维生素 D3 联合氟西汀与单用氟西汀治疗重度抑郁症患者的疗效。
在这项双盲、随机、安慰剂对照试验中，42 名符合 DSM-IV 标准的重度抑郁症患者被随机分为两组，分别接受每日 1500IU 维生素 D3 联合 20mg 氟西汀或单用氟西汀治疗 8 周。采用汉密尔顿抑郁量表（HDRS）24 项作为主要疗效指标，贝克抑郁量表（BDI）21 项作为次要疗效指标，在 2 周间隔时间评估抑郁严重程度。在基线和干预后测量血清 25(OH) 维生素 D。
40 名患者完成了试验。双向重复测量方差分析显示，基于 HDRS 和 BDI 的抑郁严重程度在干预后显著下降，两组间存在显著差异。从治疗的第四周开始，维生素 D+氟西汀联合治疗明显优于单用氟西汀。
在这项为期 8 周的试验中，维生素 D+氟西汀联合治疗在控制抑郁症状方面优于单用氟西汀。
