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维生素D对抑郁症影响的荟萃分析。

Meta-analysis of the effect of vitamin D on depression.

作者信息

Wang Lu, Su Siyuan, Liu Yongsheng

机构信息

School of Medical Imaging, Qilu Medical University, Jinan, Shandong, China.

School of Clinical Medicine, Qilu Medical University, Jinan, Shandong, China.

出版信息

Front Psychiatry. 2025 Jul 31;16:1622796. doi: 10.3389/fpsyt.2025.1622796. eCollection 2025.

DOI:10.3389/fpsyt.2025.1622796
PMID:40821024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12352333/
Abstract

OBJECTIVE

To investigate the effect of vitamin D supplementation on depressive symptoms by conducting a meta-analysis of randomized controlled trials.

METHODS

We systematically searched PubMed, EMBASE, the Cochrane Library, CNKI, VIP, Wanfang, and additional databases for relevant literature published between January 1, 2000, and October 31, 2024. Two independent reviewers screened titles, abstracts, and full texts, extracted data, and assessed study quality. RevMan 5.3 software was employed to calculate pooled effect sizes and assess heterogeneity.

RESULTS

Twenty trials met our inclusion criteria. Meta-analysis using a random-effects model demonstrated that vitamin D supplementation significantly reduced depressive symptom scores compared to controls (standardized mean difference [SMD] = -0.36; 95% confidence interval [CI], -0.52 to -0.20; P < 0.00001).

CONCLUSION

Our findings indicate that vitamin D supplementation is associated with a moderate but statistically significant improvement in depressive symptoms. These results support the potential role of vitamin D as an adjunctive treatment for depression, particularly in individuals with baseline deficiency.

摘要

目的

通过对随机对照试验进行荟萃分析，探讨补充维生素D对抑郁症状的影响。

方法

我们系统检索了PubMed、EMBASE、Cochrane图书馆、中国知网、维普资讯、万方数据以及其他数据库，以查找2000年1月1日至2024年10月31日期间发表的相关文献。两名独立评审员筛选标题、摘要和全文，提取数据并评估研究质量。使用RevMan 5.3软件计算合并效应量并评估异质性。

结果

20项试验符合我们的纳入标准。采用随机效应模型进行的荟萃分析表明，与对照组相比，补充维生素D显著降低了抑郁症状评分（标准化均值差[SMD]=-0.36；95%置信区间[CI]，-0.52至-0.20；P<0.00001）。

结论

我们的研究结果表明，补充维生素D与抑郁症状的适度但具有统计学意义的改善相关。这些结果支持了维生素D作为抑郁症辅助治疗手段的潜在作用，尤其是在基线缺乏维生素D的个体中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/1be98f151906/fpsyt-16-1622796-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/f903d7c04338/fpsyt-16-1622796-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/7ef220d54b5e/fpsyt-16-1622796-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/118a523c6702/fpsyt-16-1622796-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/382048170a75/fpsyt-16-1622796-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/61509db8b396/fpsyt-16-1622796-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/1903c2141a72/fpsyt-16-1622796-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/fff11f55103e/fpsyt-16-1622796-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/40870754b2f7/fpsyt-16-1622796-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/ef13170a1ede/fpsyt-16-1622796-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/7b5a96d6f56b/fpsyt-16-1622796-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/6507c41ab6f0/fpsyt-16-1622796-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/1be98f151906/fpsyt-16-1622796-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/f903d7c04338/fpsyt-16-1622796-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/7ef220d54b5e/fpsyt-16-1622796-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/118a523c6702/fpsyt-16-1622796-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/382048170a75/fpsyt-16-1622796-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/61509db8b396/fpsyt-16-1622796-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/1903c2141a72/fpsyt-16-1622796-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/fff11f55103e/fpsyt-16-1622796-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/40870754b2f7/fpsyt-16-1622796-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/ef13170a1ede/fpsyt-16-1622796-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/7b5a96d6f56b/fpsyt-16-1622796-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/6507c41ab6f0/fpsyt-16-1622796-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1b/12352333/1be98f151906/fpsyt-16-1622796-g012.jpg

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本文引用的文献

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The effect of vitamin D supplementation on depression: a systematic review and dose-response meta-analysis of randomized controlled trials.补充维生素D对抑郁症的影响：一项随机对照试验的系统评价和剂量反应荟萃分析
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Effects of probiotic and vitamin D co-supplementation on clinical symptoms, mental health, and inflammation in adult patients with migraine headache: a randomized, triple-blinded, placebo-controlled trial.益生菌和维生素 D 联合补充对偏头痛成年患者临床症状、心理健康和炎症的影响：一项随机、三盲、安慰剂对照试验。
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Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.
一项 8 周高剂量维生素 D 补充对新冠后综合征疲劳和神经精神症状影响的随机对照试验。
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Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets.炎症机制在重度抑郁症中的作用：从病因到潜在的药理学靶点
Cells. 2024 Feb 28;13(5):423. doi: 10.3390/cells13050423.
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The Effect of Probiotic Supplementation on the Gut-Brain Axis in Psychiatric Patients.补充益生菌对精神科患者肠道-脑轴的影响。
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