Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
J Clin Invest. 2012 Nov;122(11):3852-4. doi: 10.1172/JCI66455. Epub 2012 Oct 24.
Acute kidney injury (AKI) often results from ischemia reperfusion, sepsis, or exposure to nephrotoxins and is associated with a high rate of mortality and morbidity. Advances in understanding the pathophysiology of AKI may lead to the development of specific therapies. Although there is evidence of an important role for immune cells in AKI, the specific relevant populations and the mechanisms of their actions are unclear. In this issue of the JCI, Li et al. demonstrate that adenosine manipulates DC responses to kidney injury, raising hope that immunotherapy could be a tangible approach to AKI.
急性肾损伤(AKI)通常由缺血再灌注、脓毒症或接触肾毒物引起,与高死亡率和高发病率相关。对 AKI 病理生理学的深入了解可能会带来特异性治疗方法的发展。尽管有证据表明免疫细胞在 AKI 中发挥重要作用,但具体相关细胞群及其作用机制尚不清楚。在本期 JCI 中,Li 等人证明了腺苷可调节 DC 对肾损伤的反应,这为免疫治疗可能成为 AKI 的一种切实可行的方法带来了希望。