Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA.
Postgrad Med. 2012 Sep;124(5):136-42. doi: 10.3810/pgm.2012.09.2599.
To elucidate the relationship between low circulating serum vitamin D levels and predisease conditions (ie, prediabetes and prehypertension) in healthy Mexican American adults.
Analyses were conducted using data from the United States National Health and Nutrition Examination Survey (NHANES) from 2001 through 2006. Free-living (ie, community-dwelling, nonimprisoned) adult Mexican American subjects (N = 788; men, n = 443; women, n = 345) who had provided written informed consent and had no history of diabetes, hypertension, dyslipidemia, metabolic syndrome, and/or cardiovascular disease were included in this report. Participants were not ingesting any prescription medications, nor did they exhibit any evidence of malabsorption. Participants were determined to be disease free.
The mean serum vitamin D level for Mexican American adults (N = 788) of 50.5 nmol/L was significantly higher (P < 0.0001) than the mean of 35.9 nmol/L for non-Hispanic black adults (n = 621), and significantly lower (P < 0.0001) than the mean of 65.0 nmol/L for non-Hispanic white adults (n = 1711). Although age, sex, and body mass index were all significantly associated with prehypertension and prediabetes, no such association was found for serum vitamin D levels.
A successive, incremental shift of approximately 15 nmol/L in vitamin D distribution was seen in the transition from the dark-skinned non-Hispanic black population to the brown-skinned Mexican American population, and from the brown-skinned Mexican American population to the non-Hispanic white population. In contrast to the non-Hispanic black and non-Hispanic white populations, wherein previous studies found that serum vitamin D levels below the 75th percentile were associated with prediabetes and prehypertension, no such association was detected among the Mexican American population. The reason for this lack of association among the Mexican American population is unclear.
阐明健康墨西哥裔美国成年人中循环血清维生素 D 水平低与前期疾病（即糖尿病前期和高血压前期）之间的关系。
使用 2001 年至 2006 年美国国家健康和营养检查调查（NHANES）的数据进行分析。本报告纳入了提供书面知情同意书且无糖尿病、高血压、血脂异常、代谢综合征和/或心血管疾病病史的自由生活（即社区居住、未被监禁）成年墨西哥裔美国受试者（N=788；男性，n=443；女性，n=345）。参与者未服用任何处方药，也没有任何吸收不良的证据。参与者被确定为无疾病。
墨西哥裔美国成年人（N=788）的平均血清维生素 D 水平为 50.5 nmol/L，明显高于非西班牙裔黑成年人（n=621）的平均水平 35.9 nmol/L（P<0.0001），也明显低于非西班牙裔白成年人（n=1711）的平均水平 65.0 nmol/L（P<0.0001）。尽管年龄、性别和体重指数均与高血压前期和糖尿病前期显著相关，但血清维生素 D 水平与高血压前期和糖尿病前期无关联。
在从深色非西班牙裔黑人人群到棕色皮肤的墨西哥裔美国人人群，以及从棕色皮肤的墨西哥裔美国人人群到非西班牙裔白人人群的转变过程中，维生素 D 分布逐渐递增，约增加 15 nmol/L。与非西班牙裔黑人和非西班牙裔白人人群中的先前研究不同，这些研究发现血清维生素 D 水平低于第 75 百分位数与糖尿病前期和高血压前期有关，而在墨西哥裔美国人人群中未发现这种关联。墨西哥裔美国人人群中缺乏这种关联的原因尚不清楚。
