Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA.
Diabetes Care. 2011 Mar;34(3):658-60. doi: 10.2337/dc10-1829. Epub 2011 Jan 31.
To determine whether modest elevations of fasting serum glucose (FSG) and resting blood pressure (BP) in healthy adults are associated with differential serum vitamin D concentrations.
Disease-free adults in the National Health and Nutrition Examination Survey 2001-2006 were assessed. Prediabetes (PreDM) and prehypertension (PreHTN) were diagnosed using American Diabetes Association and Seventh Report of the Joint National Committee on Prevention, Detection, and Treatment of High Blood Pressure criteria: FSG 100-125 mg/dL and systolic BP 120-139 mmHg and/or diastolic BP 80-89 mmHg. Logistic regression was used to assess the effects of low vitamin D levels on the odds for PreDM and PreHTN in asymptomatic adults (n = 1,711).
The odds ratio for comorbid PreDM and PreHTN in Caucasian men (n = 898) and women (n = 813) was 2.41 (P < 0.0001) with vitamin D levels ≤ 76.3 versus >76.3 nmol/L after adjusting for age, sex, and BMI.
This study strengthens the plausibility that low serum vitamin D levels elevate the risk for early-stage diabetes (PreDM) and hypertension (PreHTN).
确定健康成年人空腹血糖（FSG）和静息血压（BP）适度升高是否与血清维生素 D 浓度的差异有关。
评估了 2001-2006 年国家健康和营养调查中的无病成年人。使用美国糖尿病协会和第七份联合国家委员会关于预防、检测和治疗高血压报告的标准诊断前驱糖尿病（PreDM）和前驱高血压（PreHTN）：FSG 100-125mg/dL 和收缩压 120-139mmHg 和/或舒张压 80-89mmHg。使用逻辑回归评估无症状成年人（n=1711）中低维生素 D 水平对 PreDM 和 PreHTN 发病几率的影响。
在白人男性（n=898）和女性（n=813）中，同时患有 PreDM 和 PreHTN 的合并几率为 2.41（P<0.0001），维生素 D 水平≤76.3 nmol/L 与>76.3 nmol/L 相比。调整年龄、性别和 BMI 后。
本研究进一步证实了低血清维生素 D 水平增加早期糖尿病（PreDM）和高血压（PreHTN）风险的可能性。
