Department of Orthopaedics,University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14625, USA.
J Bone Joint Surg Am. 2012 Dec 5;94(23):2161-6. doi: 10.2106/JBJS.K.01598.
Smoking is associated with low back pain, intervertebral disc disease, inferior patient outcomes following surgical interventions, and increased rates of postoperative complications. The purpose of the present study was to examine the effect of smoking and smoking cessation on pain and disability in patients with painful spinal disorders.
We examined a prospectively maintained database of records for 5333 patients with axial or radicular pain from a spinal disorder with regard to smoking history and the patient assessment of pain on four visual analog scales during the course of care. Confounding factors, including secondary gain, sex, age, and body mass index, were also examined. The mean duration of follow-up was eight months. Multivariate statistical analysis was performed with variables including smoking status, secondary gain status, sex, depression, and age as predictors of pain and disability.
Compared with patients who had never smoked, patients who were current smokers reported significantly greater pain in all visual analog scale pain ratings (p < 0.001). The mean improvement in reported pain over the course of care was significantly different between nonsmokers and current smokers (p <0.001). Compared with patients who had continued to smoke, those who had quit smoking during the course of care reported significantly greater improvement in pain in visual analog scale pain ratings for worst (p = 0.013), current (p < 0.05), and average weekly pain (p = 0.024). The mean improvement in the visual analog scale pain ratings was clinically important in patients in all three groups of nonsmokers. As a group, those who had continued smoking during treatment had no clinically important improvement in reported pain.
Given a strong association between improved patient-reported pain and smoking cessation, this study supports the need for smoking cessation programs for patients with a painful spinal disorder.
吸烟与腰痛、椎间盘疾病、手术干预后患者预后较差以及术后并发症发生率增加有关。本研究旨在探讨吸烟和戒烟对有疼痛性脊柱疾病患者疼痛和残疾的影响。
我们对 5333 例有轴性或根性疼痛的脊柱疾病患者的前瞻性维护数据库进行了检查,内容包括吸烟史和患者在治疗过程中对 4 个视觉模拟量表的疼痛评估。还检查了混杂因素,包括继发获益、性别、年龄和体重指数。平均随访时间为 8 个月。采用多元统计分析,以吸烟状况、继发获益状况、性别、抑郁和年龄作为疼痛和残疾的预测因子。
与从不吸烟的患者相比,当前吸烟者在所有视觉模拟量表疼痛评分中报告的疼痛明显更严重(p<0.001)。在治疗过程中,报告的疼痛平均改善程度在不吸烟者和当前吸烟者之间存在显著差异(p<0.001)。与在治疗过程中继续吸烟的患者相比,在治疗过程中戒烟的患者在视觉模拟量表疼痛评分的最差(p=0.013)、当前(p<0.05)和平均每周疼痛(p=0.024)方面报告的疼痛改善程度显著更大。在所有三组不吸烟者中,视觉模拟量表疼痛评分的平均改善程度具有临床意义。作为一个整体,在治疗过程中继续吸烟的患者在报告的疼痛方面没有临床意义上的显著改善。
鉴于患者报告的疼痛改善与戒烟之间存在很强的关联,本研究支持对有疼痛性脊柱疾病的患者实施戒烟计划的必要性。