Ligand- and pH-induced conformational changes of RNA domain helix 69 revealed by 2-aminopurine fluorescence.
作者信息
Sakakibara Yogo, Abeysirigunawardena Sanjaya C, Duc Anne-Cécile E, Dremann Danielle N, Chow Christine S
机构信息
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
出版信息
Angew Chem Int Ed Engl. 2012 Nov 26;51(48):12095-8. doi: 10.1002/anie.201206000. Epub 2012 Oct 24.
Abstract
摘要
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Role of pseudouridine in structural rearrangements of helix 69 during bacterial ribosome assembly.假尿嘧啶核苷在细菌核糖体组装过程中 69 号螺旋结构重排中的作用。
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A powerful approach for the selection of 2-aminopurine substitution sites to investigate RNA folding.一种用于选择 2-氨基嘌呤取代位点以研究 RNA 折叠的有效方法。
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Comparison of solution conformations and stabilities of modified helix 69 rRNA analogs from bacteria and human.细菌和人类来源的修饰 69 号螺旋 RNA 类似物的构象和稳定性比较。
Biopolymers. 2012 Feb;97(2):94-106. doi: 10.1002/bip.21706. Epub 2011 Aug 19.
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Helix 69 is key for uniformity during substrate selection on the ribosome.螺旋 69 是核糖体上底物选择过程中保持一致性的关键。
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Structures of the bacterial ribosome in classical and hybrid states of tRNA binding.细菌核糖体在 tRNA 结合的经典状态和混合状态下的结构。
Science. 2011 May 20;332(6032):981-4. doi: 10.1126/science.1202692.
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Probing conformational states of modified helix 69 in 50S ribosomes.探测 50S 核糖体中修饰的螺旋 69 的构象状态。
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Structural rearrangements of the ribosome at the tRNA proofreading step.核糖体在 tRNA 校对步骤中的结构重排。
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Binding of aminoglycoside antibiotics to helix 69 of 23S rRNA.氨基糖苷类抗生素与 23S rRNA 螺旋 69 的结合。
Nucleic Acids Res. 2010 May;38(9):3094-105. doi: 10.1093/nar/gkp1253. Epub 2010 Jan 27.
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Aminoglycoside activity observed on single pre-translocation ribosome complexes.在单个翻译前核糖体复合物上观察到的氨基糖苷活性。
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