HER-2/neu的预后意义及印度东部加尔各答一家专业乳腺诊所乳腺癌患者的生存情况

Prognostic significance of HER-2/neu and survival of breast cancer patients attending a specialized breast clinic in Kolkata, Eastern India.

作者信息

Jana Debarshi, Mandal Syamsundar, Mukhopadhyay Madhumita, Mitra Debabrata, Mukhopadhyay Sunit K, Sarkar Diptendra Kumar

机构信息

Breast Cancer Research Unit, Breast Service, Institute of Post Graduate Medical Education and Research (IPGME and R) and Seth Sukhlal Karnani Memorial Hospital (SSKM), Kolkata, India.

出版信息

Asian Pac J Cancer Prev. 2012;13(8):3851-5. doi: 10.7314/apjcp.2012.13.8.3851.

DOI:10.7314/apjcp.2012.13.8.3851

PMID:23098482

Abstract

INTRODUCTION

The worldwide incidence of breast cancer has increased rapidly in recent years. The scenario of Eastern India is also showing the same trend. It is necessary to study the utility of HER-2/neu as a prognostic factor in breast cancer survival. However, there have not been detailed studies in this respect with the breast cancer patients of Eastern India. Thus this study was conducted.

MATERIALS AND METHODS

In this hospital-based study 86 breast cancer patients attending a breast clinic of a reputed institute of Eastern India and having invasive ductal carcinomas were observed for a period of 5 years after surgery. Associations between 5 years observed survival and status of ER, PR and HER-2/neu of the patients were critically evaluated.

RESULTS

There was statistically significant association between survival pattern for 5 years and the HER-2/neu status (p=0.00001). Better survival was observed for the patients with HER-2/neu negative tumors 67(100%) compared to HER-2/neu positive tumors 7(36.8%).

CONCLUSION

There is strong interaction between survival and HER-2/neu expression of breast cancer patients. Thus the patients with HER-2/neu positive tumors need to be treated aggressively.

摘要