Ürün Yüksel, Utkan Güngör, Yalcin Şuayib, Coşkun Hasan Şenol, Koçer Murat, Özdemir Nuriye Yildirim, Kaplan Mehmet Ali, Arslan Ülkü Yalçintaş, Özdemir Feyyaz, Öztuna Derya, Akbulut Hakan, İçli Fikri
Faculty of Medicine, Ankara University, Turkey.
Asian Pac J Cancer Prev. 2012;13(8):4129-31.
An association between the ABO blood group and the risk of certain malignancies, including pancreatic and gastric cancer, has been reported previously. However, it is unclear whether this association is valid for gastrointestinal stromal tumors (GIST). In this study, ABO blood groups and the Rh factor were investigated in a series of GIST cases.
In 162 patients with GIST, blood group and Rh factor were examined and compared with a control group of 3,022,883 healthy volunteer blood donors of the Turkish Red Crescent between 2004 and 2011. The relationship of blood groups with tumor size, mitotic activity, and age were also evaluated.
Overall, the ABO blood group and Rh factor distributions of the 162 patients with GIST were similar to those of the general population. There were no significant differences between both ABO blood types and Rh factor in terms of tumor size, mitotic activity, and age.
This is the first study reported on this issue. In our study, we didn't find any relationship between GIST and ABO blood group and Rh factor. However further studies with larger number of patients are needed to establish the role of blood groups in this population.
先前已有报道称ABO血型与某些恶性肿瘤（包括胰腺癌和胃癌）的风险之间存在关联。然而，这种关联对于胃肠道间质瘤（GIST）是否有效尚不清楚。在本研究中，对一系列GIST病例的ABO血型和Rh因子进行了调查。
对162例GIST患者的血型和Rh因子进行了检测，并与2004年至2011年间土耳其红新月会的3,022,883名健康志愿献血者组成的对照组进行了比较。还评估了血型与肿瘤大小、有丝分裂活性和年龄之间的关系。
总体而言，162例GIST患者的ABO血型和Rh因子分布与普通人群相似。在肿瘤大小、有丝分裂活性和年龄方面，ABO血型和Rh因子两者之间均无显著差异。
这是关于该问题的首次报道研究。在我们的研究中，未发现GIST与ABO血型和Rh因子之间存在任何关系。然而，需要更多患者的进一步研究来确定血型在该人群中的作用。
