Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, USA.
Arch Gynecol Obstet. 2009 Dec;280(6):917-9. doi: 10.1007/s00404-009-1031-2. Epub 2009 Mar 20.
The aim of this investigation was twofold: first, to demonstrate an association between endometriosis, ABO blood groups and Rhesus factor and, second, to show potential correlation of ABO blood group and stages of endometriosis.
Two hundred and thirty-one women with endometriosis and 166 infertile women without endometriosis were studied retrospectively at the Yale University Hospital. All the cases were diagnosed by laparoscopy and in all of them ABO blood groups and Rhesus factor were determined by standard techniques. Women with endometriosis were divided into two groups according to the stage: Group 1 included 124 cases with stages I and II, and Group 2, 107 women with stages III and IV. Statistical methods included chi(2) and odds ratios (95% CI).
The identified distribution of ABO and Rh blood groups in women with endometriosis differed significantly from that of the women without endometriosis [chi(2) = 26.27, (P < 0.001); chi(2) = 18.71, (P < 0.001), respectively]. The blood group A was more predominant in women with endometriosis, while blood group O was less predominant. The overall risk of women with endometriosis and A blood group was 2.89 (95%CI, 1.85-4.52). No significant difference was detected in ABO and Rh blood groups in women with endometriosis according to the severity of disease.
Women with endometriosis have a 2.9-fold increased risk in the A blood group distribution. The role of blood groups in the development of endometriosis remains to be determined.
本研究旨在双重验证：第一，子宫内膜异位症与 ABO 血型和 Rh 因子之间的相关性；第二，显示 ABO 血型与子宫内膜异位症分期之间的潜在相关性。
耶鲁大学医院回顾性研究了 231 例子宫内膜异位症患者和 166 例无子宫内膜异位症的不孕妇女。所有病例均经腹腔镜诊断，所有患者均采用标准技术确定 ABO 血型和 Rh 因子。根据分期将子宫内膜异位症患者分为两组：第 1 组包括 124 例 I 期和 II 期患者，第 2 组包括 107 例 III 期和 IV 期患者。统计方法包括卡方检验和比值比（95%置信区间）。
患有子宫内膜异位症的妇女的 ABO 和 Rh 血型分布与无子宫内膜异位症的妇女有显著差异[卡方检验=26.27，（P<0.001）；卡方检验=18.71，（P<0.001）]。子宫内膜异位症患者中 A 血型更为常见，而 O 血型则较少见。患有子宫内膜异位症且血型为 A 的妇女的总体风险为 2.89（95%CI，1.85-4.52）。根据疾病的严重程度，子宫内膜异位症患者的 ABO 和 Rh 血型无明显差异。
患有子宫内膜异位症的妇女 A 血型分布的风险增加了 2.9 倍。血型在子宫内膜异位症发展中的作用仍有待确定。
