Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Germany.
Ageing Res Rev. 2013 Jan;12(1):365-75. doi: 10.1016/j.arr.2012.10.002. Epub 2012 Oct 23.
We have conducted a comprehensive literature review regarding the effect of vitamin E on lifespan in model organisms including single-cell organisms, rotifers, Caenorhabditis elegans, Drosophila melanogaster and laboratory rodents. We searched Pubmed and ISI Web of knowledge for studies up to 2011 using the terms "tocopherols", "tocotrienols", "lifespan" and "longevity" in the above mentioned model organisms. Twenty-four studies were included in the final analysis. While some studies suggest an increase in lifespan due to vitamin E, other studies did not observe any vitamin E-mediated changes in lifespan in model organisms. Furthermore there are several studies reporting a decrease in lifespan in response to vitamin E supplementation. Different outcomes between studies may be partly related to species-specific differences, differences in vitamin E concentrations and the vitamin E congeners administered. The findings of our literature review suggest that there is no consistent beneficial effect of vitamin E on lifespan in model organisms which is consistent with reports in human intervention studies.
我们对维生素 E 对包括单细胞生物、轮虫、秀丽隐杆线虫、黑腹果蝇和实验鼠在内的模式生物的寿命的影响进行了全面的文献回顾。我们在 Pubmed 和 ISI Web of knowledge 上使用了“生育酚”、“三烯生育酚”、“寿命”和“长寿”等术语，检索了截止到 2011 年的相关研究。最终有 24 项研究被纳入了分析。虽然有些研究表明维生素 E 能延长寿命，但其他研究并没有观察到维生素 E 对模式生物的寿命有任何影响。此外，还有一些研究报告称，维生素 E 的补充会导致寿命缩短。不同研究之间的结果差异可能部分与物种特异性差异、维生素 E 浓度和给予的维生素 E 同系物有关。我们的文献综述结果表明，维生素 E 对模式生物的寿命没有一致的有益影响，这与人类干预研究的报告一致。
